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| Content Provider | Springer Nature : BioMed Central |
|---|---|
| Author | Li, Dengliang Cui, Zhanding Li, Guohua Zhang, Liangting Zhang, Ying Zhao, Han Zhang, Shuang Guo, Yanbing Zhao, Yanli Men, Fanxing Zhao, Shihui Shao, Jiang Du, Dongju Huang, Hailong Wang, Kai Hu, Guixue Li, Tiansong Zhao, Yongkun |
| Abstract | Background Feline calicivirus (FCV) is a common and highly prevalent pathogen causing upper respiratory diseases in kittens and felines in recent years. Due to the substantial genetic variability of the viral genes, existing vaccines cannot provide complete protection. Therefore, research on FCV antiviral drugs has received much attention. Results In this study, we found that copper chloride had dose-dependent antiviral effects on FCV in F81 cells. We also found that the combination of copper chloride and ribavirin had a synergistic protective effect against FCV in F81 cells. In contrast, the combination of copper chloride and horse anti-FCV immunoglobulin F (ab’)2 showed an antagonistic effect, likely because copper chloride has an effect on F (ab’)2 immunoglobulin; however, further research is needed to clarify this supposition. Conclusions In summary, we found that copper chloride had low cytotoxicity and significant antiviral effects on FCV in F81 cells, providing a new drug candidate for the prevention and treatment of FCV infection. |
| Related Links | https://bmcvetres.biomedcentral.com/counter/pdf/10.1186/s12917-020-02441-0.pdf |
| Ending Page | 9 |
| Page Count | 9 |
| Starting Page | 1 |
| File Format | HTM / HTML |
| ISSN | 17466148 |
| DOI | 10.1186/s12917-020-02441-0 |
| Journal | BMC Veterinary Research |
| Issue Number | 1 |
| Volume Number | 16 |
| Language | English |
| Publisher | BioMed Central |
| Publisher Date | 2020-07-06 |
| Access Restriction | Open |
| Subject Keyword | Veterinary Medicine Veterinary Science Zoology Transgenics Feline calicivirus Copper chloride Antiviral effect Synergistic protective effect Antagonistic effect Veterinary Medicine/Veterinary Science |
| Content Type | Text |
| Resource Type | Article |
| Subject | Veterinary Medicine |
| Journal Impact Factor | 2.3/2023 |
| 5-Year Journal Impact Factor | 2.6/2023 |
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