NDLI: miRNAs can be generally associated with human pathologies as exemplified for miR-144*

Content Provider	Springer Nature : BioMed Central
Author	Keller, Andreas Leidinger, Petra Vogel, Britta Backes, Christina ElSharawy, Abdou Galata, Valentina Mueller, Sabine C Marquart, Sabine Schrauder, Michael G Strick, Reiner Bauer, Andrea Wischhusen, Jörg Beier, Markus Kohlhaas, Jochen Katus, Hugo A Hoheisel, Jörg Franke, Andre Meder, Benjamin Meese, Eckart
Abstract	Background miRNA profiles are promising biomarker candidates for a manifold of human pathologies, opening new avenues for diagnosis and prognosis. Beyond studies that describe miRNAs frequently as markers for specific traits, we asked whether a general pattern for miRNAs across many diseases exists. Methods We evaluated genome-wide circulating profiles of 1,049 patients suffering from 19 different cancer and non-cancer diseases as well as unaffected controls. The results were validated on 319 individuals using qRT-PCR. Results We discovered 34 miRNAs with strong disease association. Among those, we found substantially decreased levels of hsa-miR-144* and hsa-miR-20b with AUC of 0.751 (95% CI: 0.703–0.799), respectively. We also discovered a set of miRNAs, including hsa-miR-155, as rather stable markers, offering reasonable control miRNAs for future studies. The strong downregulation of hsa-miR-144 and the less variable pattern of hsa-miR-155* has been validated in a cohort of 319 samples in three different centers. Here, breast cancer as an additional disease phenotype not included in the screening phase has been included as the 20th trait. Conclusions Our study on 1,368 patients including 1,049 genome-wide miRNA profiles and 319 qRT-PCR validations further underscores the high potential of specific blood-borne miRNA patterns as molecular biomarkers. Importantly, we highlight 34 miRNAs that are generally dysregulated in human pathologies. Although these markers are not specific to certain diseases they may add to the diagnosis in combination with other markers, building a specific signature. Besides these dysregulated miRNAs, we propose a set of constant miRNAs that may be used as control markers.
Related Links	https://bmcmedicine.biomedcentral.com/counter/pdf/10.1186/s12916-014-0224-0.pdf
Ending Page	12
Page Count	12
Starting Page	1
File Format	HTM / HTML
ISSN	17417015
DOI	10.1186/s12916-014-0224-0
Journal	BMC Medicine
Issue Number	1
Volume Number	12
Language	English
Publisher	BioMed Central
Publisher Date	2014-12-03
Access Restriction	Open
Subject Keyword	Medicine Public Health Biomedicine Bioinformatics Biomarker Microarray miRNA Medicine/Public Health
Content Type	Text
Resource Type	Article
Subject	Medicine
Journal Impact Factor	7.1/2023
5-Year Journal Impact Factor	8.8/2023

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1	Ministry of Education (GoI), Department of Higher Education	Sanctioning Authority	https://www.education.gov.in/ict-initiatives
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3	National Digital Library of India Office, Indian Institute of Technology Kharagpur	The administrative and infrastructural headquarters of the project	Dr. B. Sutradhar bsutra@ndl.gov.in
4	Project PI / Joint PI	Principal Investigator and Joint Principal Investigators of the project	Dr. B. Sutradhar bsutra@ndl.gov.in Prof. Saswat Chakrabarti will be added soon
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