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| Content Provider | Springer Nature : BioMed Central |
|---|---|
| Author | Rebouças de Araújo, Ítalo Diego Coriolano de Aquino, Nayara Véras de Aguiar Guerra, Andreza Conceição Ferreira de Almeida Júnior, Renato Mendonça Araújo, Renata Fernandes de Araújo Júnior, Raimundo Silva Farias, Kléber Juvenal Fernandes, José Veríssimo Sousa Andrade, Vânia |
| Abstract | Background This study evaluated the in vitro activity of essential oil extracted from the leaves of Myracrodruon urundeuva. Methods The oil was obtained by hydro-distillation and characterized by Gas Chromatography coupled to Mass Spectrometry (GC-MS) and Gas Chromatography with Flame Ionization Detector (GC-FID). The antibacterial activity was evaluated by the broth microdilution technique and the MIF was determined by using growth indicator CTT (2,3,5-triphenyl-tetrazolium) and CBM in BHI agar. The oil’s cytotoxicity was evaluated in HeLa, HEK-293, and Vero E6 cells using MTT, 3- (4,5-dimethylthiazol-2-yl) -2,5-diphenyl tetrazolium. Results The oil showed chemical markers, including α-pinene (87.85%), trans-caryophyllene (1.57%), limonene (1.49%) and β -pinene (1.42%), and activity against all strains: Staphylococcus aureus (MIC = MBC = 0.22 mg/mL), Staphylococcus epidermidis (MIC = 0.11 mg/mL and MBC = 0.22 mg/mL), Escherichia coli (MIC = 0.88 mg/mL and MBC = 1.75 mg/mL), Pseudomonas aeruginosa (MIC = MBC = 7 mg/mL) and Salmonella Enteritidis (MIC = MBC = 0.44 mg/mL). In vitro cytotoxicity tests showed that the oil is not toxic and has slight antitumor activity. Conclusions We conclude that the M. urundeuva oil results are promising, with prospects of being pharmacologically viable. |
| Related Links | https://bmccomplementmedtherapies.biomedcentral.com/counter/pdf/10.1186/s12906-017-1918-6.pdf |
| Ending Page | 8 |
| Page Count | 8 |
| Starting Page | 1 |
| File Format | HTM / HTML |
| ISSN | 26627671 |
| DOI | 10.1186/s12906-017-1918-6 |
| Journal | BMC Complementary Medicine and Therapies |
| Issue Number | 1 |
| Volume Number | 17 |
| Language | English |
| Publisher | BioMed Central |
| Publisher Date | 2017-08-22 |
| Access Restriction | Open |
| Subject Keyword | Complementary & Alternative Medicine Internal Medicine Chiropractic Medicine Myracrodruon urundeuva Bactericidal activity Minimum inhibitory concentration Chemical characterization Essential oil Cytotoxicity |
| Content Type | Text |
| Resource Type | Article |
| Subject | Complementary and Alternative Medicine |
| Journal Impact Factor | 3.3/2023 |
| 5-Year Journal Impact Factor | 3.6/2023 |
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