NDLI: A comparative study of microbial changes in dental plaque before and after single- and multiappointment treatments in patients with severe early childhood caries

Content Provider	Springer Nature : BioMed Central
Author	Ma, Shi Ying Zhou, Qing Nan Cai, Shuang Zhou, Yan Zhang, Xiao Yu Feng, Xiao Yu Diao, Shu Xi, Jin Qiu Yu, Guo Xia Shang, Jia Jian Yang, Ning Yan
Abstract	Background The status of dental caries is closely related to changes in the oral microbiome. In this study, we compared the diversity and structure of the dental plaque microbiome in children with severe early childhood caries (S-ECC) before and after general anaesthesia and outpatient treatment. Methods Forty children aged 3 to 5 years with S-ECC who had completed whole-mouth dental treatment under general anaesthesia (C1) or in outpatient settings (C2) were selected, 20 in each group. The basic information and oral health status of the children were recorded, and the microbial community structure and diversity of dental plaque before treatment (C1, C2), the day after treatment(C2_0D), 7 days after treatment (C1_7D, C2_7D), 1 month after treatment (C1_1M, C2_1M), and 3 months after treatment (C1_3M, C2_3M) were analysed via 16 S rRNA high-throughput sequencing technology. Results (1) The alpha diversity test showed that the flora richness in the multiappointment group was significantly greater at posttreatment than at pretreatment (P < 0.05), and the remaining alpha diversity index did not significantly differ between the 2 groups (P > 0.05). The beta diversity analysis revealed that the flora structures of the C1_7D group and the C2_3M group were significantly different from those of the other time points within the respective groups (P < 0.05). (2) The core flora existed in both the pre- and posttreatment groups, and the proportion of their flora abundance could be altered depending on the caries status of the children in both groups. Leptotrichia abundance was significantly (P < 0.05) lower at 7 days posttreatment in both the single- and multiappointment groups. Corynebacterium and Corynebacterium_matruchotii were significantly more abundant in the C1_1M and C1_3M groups than in the C1 and C1_7D groups (P < 0.05). Streptococcus, Haemophilus and Haemophilus_parainfluenzae were significantly more abundant in the C1_7D group than in the other groups (P < 0.05). Conclusion A single session of treatment under general anaesthesia can cause dramatic changes in the microbial community structure and composition within 7 days after treatment, whereas treatment over multiple appointments may cause slow changes in oral flora diversity.
Related Links	https://bmcoralhealth.biomedcentral.com/counter/pdf/10.1186/s12903-024-04458-5.pdf
Ending Page	12
Page Count	12
Starting Page	1
File Format	HTM / HTML
ISSN	14726831
DOI	10.1186/s12903-024-04458-5
Journal	BMC Oral Health
Issue Number	1
Volume Number	24
Language	English
Publisher	BioMed Central
Publisher Date	2024-06-15
Access Restriction	Open
Subject Keyword	Dentistry Oral and Maxillofacial Surgery Severe early childhood caries Dental treatment under general anaesthesia Multiappointment treatment 16S amplicon sequencing Oral core flora
Content Type	Text
Resource Type	Article
Subject	Dentistry
Journal Impact Factor	2.6/2023
5-Year Journal Impact Factor	3.2/2023

Sl.	Authority	Responsibilities	Communication Details
1	Ministry of Education (GoI), Department of Higher Education	Sanctioning Authority	https://www.education.gov.in/ict-initiatives
2	Indian Institute of Technology Kharagpur	Host Institute of the Project: The host institute of the project is responsible for providing infrastructure support and hosting the project	https://www.iitkgp.ac.in
3	National Digital Library of India Office, Indian Institute of Technology Kharagpur	The administrative and infrastructural headquarters of the project	Dr. B. Sutradhar bsutra@ndl.gov.in
4	Project PI / Joint PI	Principal Investigator and Joint Principal Investigators of the project	Dr. B. Sutradhar bsutra@ndl.gov.in Prof. Saswat Chakrabarti will be added soon
5	Website/Portal (Helpdesk)	Queries regarding NDLI and its services	support@ndl.gov.in
6	Contents and Copyright Issues	Queries related to content curation and copyright issues	content@ndl.gov.in
7	National Digital Library of India Club (NDLI Club)	Queries related to NDLI Club formation, support, user awareness program, seminar/symposium, collaboration, social media, promotion, and outreach	clubsupport@ndl.gov.in
8	Digital Preservation Centre (DPC)	Assistance with digitizing and archiving copyright-free printed books	dpc@ndl.gov.in
9	IDR Setup or Support	Queries related to establishment and support of Institutional Digital Repository (IDR) and IDR workshops	idr@ndl.gov.in

Streptococcus mutans-associated bacteria in dental plaque of severe early childhood caries.

Plaque biofilm microbial diversity in infants aged 12 months and their mothers with or without dental caries: a pilot study

Analysis of oral microbial dysbiosis associated with early childhood caries

Microbial Indicators of Dental Health, Dysbiosis, and Early Childhood Caries

Oral Health of Children One to Six Years after Dental Treatment under General Anaesthesia

Microbiota of Severe Early Childhood Caries before and after Therapy

Supragingival plaque microbial analysis in reflection to caries experience

Disparities in Early Childhood Caries

Carbon source utilization patterns in dental plaque and microbial responses to sucrose, lactose, and phenylalanine consumption in severe early childhood caries

A comparative study of microbial changes in dental plaque before and after single- and multiappointment treatments in patients with severe early childhood caries

Similar Documents

Streptococcus mutans-associated bacteria in dental plaque of severe early childhood caries.

Plaque biofilm microbial diversity in infants aged 12 months and their mothers with or without dental caries: a pilot study

Analysis of oral microbial dysbiosis associated with early childhood caries

Microbial Indicators of Dental Health, Dysbiosis, and Early Childhood Caries

Oral Health of Children One to Six Years after Dental Treatment under General Anaesthesia

Microbiota of Severe Early Childhood Caries before and after Therapy

Supragingival plaque microbial analysis in reflection to caries experience

Disparities in Early Childhood Caries

Carbon source utilization patterns in dental plaque and microbial responses to sucrose, lactose, and phenylalanine consumption in severe early childhood caries

A comparative study of microbial changes in dental plaque before and after single- and multiappointment treatments in patients with severe early childhood caries