NDLI: Characteristics of oral microbiome of healthcare workers in different clinical scenarios: a cross-sectional analysis

Content Provider	Springer Nature : BioMed Central
Author	Zhang, Zhixia Yu, Wenyi Li, Guangyao He, Yukun Shi, Zhiming Wu, Jing Ma, Xinqian Zhu, Yu Zhao, Lili Liu, Siqin Wei, Yue Xue, Jianbo Guo, Shuming Gao, Zhancheng
Abstract	The environment of healthcare institutes (HCIs) potentially affects the internal microecology of medical workers, which is reflected not only in the well-studied gut microbiome but also in the more susceptible oral microbiome. We conducted a prospective cross-sectional cohort study in four hospital departments in Central China. Oropharyngeal swabs from 65 healthcare workers were collected and analyzed using 16S rRNA gene amplicon sequencing. The oral microbiome of healthcare workers exhibited prominent deviations in diversity, microbial structure, and predicted function. The coronary care unit (CCU) samples exhibited robust features and stability, with significantly higher abundances of genera such as Haemophilus, Fusobacterium, and Streptococcus, and a lower abundance of Prevotella. Functional prediction analysis showed that vitamin, nucleotide, and amino acid metabolisms were significantly different among the four departments. The CCU group was at a potential risk of developing periodontal disease owing to the increased abundance of F. nucleatum. Additionally, oral microbial diversification of healthcare workers was related to seniority. We described the oral microbiome profile of healthcare workers in different clinical scenarios and demonstrated that community diversity, structure, and potential functions differed markedly among departments. Intense modulation of the oral microbiome of healthcare workers occurs because of their original departments, especially in the CCU.
Related Links	https://bmcoralhealth.biomedcentral.com/counter/pdf/10.1186/s12903-022-02501-x.pdf
Ending Page	10
Page Count	10
Starting Page	1
File Format	HTM / HTML
ISSN	14726831
DOI	10.1186/s12903-022-02501-x
Journal	BMC Oral Health
Issue Number	1
Volume Number	22
Language	English
Publisher	BioMed Central
Publisher Date	2022-11-10
Access Restriction	Open
Subject Keyword	Dentistry Oral and Maxillofacial Surgery Healthcare institutes Coronary care unit Healthcare worker 16S rRNA Oral microbiome Microbial alteration
Content Type	Text
Resource Type	Article
Subject	Dentistry
Journal Impact Factor	2.6/2023
5-Year Journal Impact Factor	3.2/2023

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