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| Content Provider | Springer Nature : BioMed Central |
|---|---|
| Author | da Silva, Felipe Rodolfo Pereira Galeno, Juliana Gomes Leal, Alessandro Luiz Araújo Bentes Koga, Reyce Santos Batista, Nayana Yared da Conceição Furtado, Silvânia Vasconcelos, Daniel Fernando Pereira Carvalho, Marcelo Diniz Barcellos, José Fernando Marques |
| Abstract | Background Chronic periodontitis (CP) is an immune-inflammatory disease that promotes tissue damage around the teeth. Among the several inflammatory mediators that orchestrate the periodontitis, there is the interleukin (IL)-2. Genetic variations in IL2 gene may be associated with the risk and severity of the disease. Contrary results are available in the literature with inconclusive findings and none meta-analysis to gather these data. Methods A literature search was performed for studies published before June 11, 2019 in diverse scientific and educational databases. The data was extracted by two investigators and the statistical evaluation was performed by Review Manager statistical program with heterogeneity (I2) and Odds Ratio (OR) with 95% of Confidence Intervals (CI) calculations and a sensitive analysis to assess the accuracy of the obtained results. The publication bias was evaluated by Begg’ and Egger’s test with Comprehensive meta-analysis software. The value of P < 0.05 was considered as significant. Results Five studies were identified in diverse ethnical groups with 1425 participants. The − 330 T/G polymorphism in IL2 gene was not significantly associated with CP in allelic evaluation (P > 0.05) as well as in the genotypic comparisons (P = 0.15). The Begg’s test and the linear regression Egger’s test did not show any evidence of publication bias risk (P > 0.05) which was corroborated by the absence of obvious asymmetry in Funnel plot graphic. Conclusions This meta-analysis showed a non-significant association between − 330 T/G polymorphism in IL2 gene and CP in any allelic evaluation. |
| Related Links | https://bmcoralhealth.biomedcentral.com/counter/pdf/10.1186/s12903-020-1034-8.pdf |
| Ending Page | 9 |
| Page Count | 9 |
| Starting Page | 1 |
| File Format | HTM / HTML |
| ISSN | 14726831 |
| DOI | 10.1186/s12903-020-1034-8 |
| Journal | BMC Oral Health |
| Issue Number | 1 |
| Volume Number | 20 |
| Language | English |
| Publisher | BioMed Central |
| Publisher Date | 2020-02-19 |
| Access Restriction | Open |
| Subject Keyword | Dentistry Oral and Maxillofacial Surgery Periodontal disease Cytokine Odds ratio Risk factor Allele |
| Content Type | Text |
| Resource Type | Article |
| Subject | Dentistry |
| Journal Impact Factor | 2.6/2023 |
| 5-Year Journal Impact Factor | 3.2/2023 |
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