NDLI: Composition and diversity of the subgingival microbiome and its relationship with age in postmenopausal women: an epidemiologic investigation

Content Provider	Springer Nature : BioMed Central
Author	LaMonte, Michael J. Genco, Robert J. Buck, Michael J. McSkimming, Daniel I. Li, Lu Hovey, Kathleen M. Andrews, Christopher A. Zheng, Wei Sun, Yijun Millen, Amy E. Tsompana, Maria Banack, Hailey R. Wactawski-Wende, Jean
Abstract	Background The extent to which the composition and diversity of the oral microbiome varies with age is not clearly understood. Methods The 16S rRNA gene of subgingival plaque in 1219 women, aged 53–81 years, was sequenced and its taxonomy annotated against the Human Oral Microbiome Database (v.14.5). Composition of the subgingival microbiome was described in terms of centered log(2)-ratio (CLR) transformed OTU values, relative abundance, and prevalence. Correlations between microbiota abundance and age were evelauted using Pearson Product Moment correlations. P-values were corrected for multiple testing using the Bonferroni method. Results Of the 267 species identified overall, Veillonella dispar was the most abundant bacteria when described by CLR OTU (mean 8.3) or relative abundance (mean 8.9%); whereas Streptococcus oralis, Veillonella dispar and Veillonella parvula were most prevalent (100%, all) when described as being present at any amount. Linear correlations between age and several CLR OTUs (Pearson r = − 0.18 to 0.18), of which 82 (31%) achieved statistical significance (P < 0.05). The correlations lost significance following Bonferroni correction. Twelve species that differed across age groups (each corrected P < 0.05); 5 (42%) were higher in women ages 50–59 compared to ≥70 (corrected P < 0.05), and 7 (48%) were higher in women 70 years and older. Conclusions We identified associations between several bacterial species and age across the age range of postmenopausal women studied. Understanding the functions of these bacteria could identify intervention targets to enhance oral health in later life.
Related Links	https://bmcoralhealth.biomedcentral.com/counter/pdf/10.1186/s12903-019-0906-2.pdf
Ending Page	44
Page Count	44
Starting Page	1
File Format	HTM / HTML
ISSN	14726831
DOI	10.1186/s12903-019-0906-2
Journal	BMC Oral Health
Issue Number	1
Volume Number	19
Language	English
Publisher	BioMed Central
Publisher Date	2019-11-13
Access Restriction	Open
Subject Keyword	Dentistry Oral and Maxillofacial Surgery Aging Women Oral Microbiome Epidemiology
Content Type	Text
Resource Type	Article
Subject	Dentistry
Journal Impact Factor	2.6/2023
5-Year Journal Impact Factor	3.2/2023

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