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| Content Provider | Springer Nature : BioMed Central |
|---|---|
| Author | Zeng, Yan-Ru Han, Zhao-Dong Wang, Cong Cai, Chao Huang, Ya-Qiang Luo, Hong-Wei Liu, Ze-Zhen Zhuo, Yang-Jia Dai, Qi-Shan Zhao, Hai-Bo Liang, Yu-Xiang Zhong, Wei-De |
| Abstract | Background The NIMA-related kinase 2 (NEK2) is a serine/threonine kinase that is involved in regulation of centrosome duplication and spindle assembly during mitosis. Dysregulation of these processes causes chromosome instability and aneuploidy, which are hallmark changes of many solid tumors. However, whether aberrant expression of NEK2 is associated with outcome of prostate cancer (PCa) patients remains to be determined. Methods Expression of NEK2 in human PCa cells and primary PCa tissues was assessed by quantitative RT-PCR. Expression of NEK2 in human PCa cells was depleted with siRNA. Effects of the depletion on cell proliferation, survival, and tumorigenicity were assessed both in vitro with cell cultures and in vivo with subcutaneous implantation of xenografts. In silico analyses of the online Taylor dataset were carried out to determine whether the expression level of NEK2 correlated with the clinicopathological characteristics of prostate cancer. Results Compared with benign human prostatic epithelial cells and tissues, the expression of NEK2 was elevated in human PCa cells and primary PCa tissues. Depleting NEK2 expression inhibited human PCa cell proliferation in vitro and xenograft growth in vivo. Expression level of NEK2 in PCa positively correlated with the Gleason score and pathologic stage of the patient. Conclusion The results suggest that overexpression of NEK2 has the potential to serve as a biomarker for PCa prognosis. Further validation with large sample pool is warrant. |
| Related Links | https://bmcurol.biomedcentral.com/counter/pdf/10.1186/s12894-015-0085-7.pdf |
| Ending Page | 8 |
| Page Count | 8 |
| Starting Page | 1 |
| File Format | HTM / HTML |
| ISSN | 14712490 |
| DOI | 10.1186/s12894-015-0085-7 |
| Journal | BMC Urology |
| Issue Number | 1 |
| Volume Number | 15 |
| Language | English |
| Publisher | BioMed Central |
| Publisher Date | 2015-08-29 |
| Access Restriction | Open |
| Subject Keyword | Urology Internal Medicine Prostate Specific Antigen Gleason Score LNCaP Cell Centrosome Duplication Bipolar Spindle Formation |
| Content Type | Text |
| Resource Type | Article |
| Subject | Urology Reproductive Medicine |
| Journal Impact Factor | 1.7/2023 |
| 5-Year Journal Impact Factor | 2/2023 |
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