NDLI: Association between sitting time at work and the onset of major depressive episode: a 1-year prospective cohort study using the Bayesian regression

Content Provider	Springer Nature : BioMed Central
Author	Watanabe, Kazuhiro Kawakami, Norito
Abstract	Background Although sedentary behavior is associated with the onset of major depressive disorder, it remains unclear whether sedentary behavior at work increases the risk of depression. The present study used the Bayesian approach to investigate the association between sitting time at work and the onset of major depressive episode (MDE). Methods A 1-year prospective cohort study was conducted among 233 Japanese workers without MDE (response rate: 4.3%). MDE onset was assessed using the self-reported WHO Composite International Diagnostic Interview version 3.0. A Bayesian Cox proportional hazard model was used to estimate the hazard ratio (HR) between long sitting time at work and MDE onset. Results A total of 231 workers were included in the analysis. During the follow-up, 1621 person-months were observed, and six participants experienced MDE onset. Incident rates per months were 0.34, 0.11, and 1.02% in short (< 7.2 h per day), medium (7.2–9.5 h), and long (9.5+ h) sitting time at work, respectively. The estimated median posterior probability distribution of the HR of long sitting time was 3.00 (95% highest density interval [HDI]: 0.73–12.03). The estimated median remained positive after adjustment for physical activity level and other covariates (HR = 2.11, 95% HDI: 0.42–10.22). The 10-base Bayesian factor for H1 (HR = 1.00) compared with the alternatives (H0, HR = 1.00) was 0.68 in the adjusted model. The analysis, which treated sitting time at work as a continuous variable, estimated that the median of the posterior probability distribution of the HR of sitting time was 0.79 (95% HDI: 0.58–1.07. The 10-base Bayesian factor was 2.73 in the linear association. Conclusions Long sitting time at work (9.5+ h per day) might be associated with MDE onset among workers. However, the linear association indicated conflicting results. Non-linear associations between sitting time and MDE onset might explain this inconsistency. The evidence for an adverse association between sitting time at work and MDE onset remains inconclusive.
Related Links	https://bmcpublichealth.biomedcentral.com/counter/pdf/10.1186/s12889-021-12059-y.pdf
Ending Page	11
Page Count	11
Starting Page	1
File Format	HTM / HTML
ISSN	14712458
DOI	10.1186/s12889-021-12059-y
Journal	BMC Public Health
Issue Number	1
Volume Number	21
Language	English
Publisher	BioMed Central
Publisher Date	2021-10-29
Access Restriction	Open
Subject Keyword	Public Health Medicine Epidemiology Biostatistics Vaccine Environmental Health Sedentary Physical activity Depressive disorder Workers Bayesian analysis Medicine/Public Health
Content Type	Text
Resource Type	Article
Subject	Public Health, Environmental and Occupational Health
Journal Impact Factor	3.5/2023
5-Year Journal Impact Factor	3.9/2023

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1	Ministry of Education (GoI), Department of Higher Education	Sanctioning Authority	https://www.education.gov.in/ict-initiatives
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