NDLI: Prevalence and characterization of hepatitis B and C virus infections in a needle-sharing population in Northern China

Content Provider	Springer Nature : BioMed Central
Author	Xu, Cheng-Jun Zhang, Cui-Ping Luo, Bi-Fen Liu, Li-Jun Wang, Yun-Zhong Wang, Xiao-Hong He, Qiu-Jie Zhou, Shan-Shan Guo, Wei-Shan Wang, Jiu-Heng Yang, Rui-Feng Zhang, Hai-Ying Rao, Hui-Ying Feng, Bo Wei, Lai
Abstract	Background The epidemiologies of hepatitis C virus (HCV) and hepatitis B virus (HBV) infections in specific populations in certain areas of China are poorly understood. A pilot survey of HCV/HBV infections was carried out in villages in Kuancheng County, Heben Province, where injection of sodium benzoate or amphetamines using shared needles has been a common practice. The aims of this study were to analyze the endemicity and characterize HCV/HBV infections in this population. Methods Data on demographic characteristics and drug abuse were collected from individuals who signed informed consent forms. Serum HCV antibody (anti-HCV), hepatitis B surface antigen (HBsAg), and hepatitis B core antibody (anti-HBc) were measured in all participants. HCV RNA was measured in samples positive for anti-HCV using real-time polymerase chain reaction. Results Among 852 participants from 11 villages, 49.9% had used sodium benzoate or amphetamine at least once, by intravenous injection. The overall prevalence of anti-HCV, HCV RNA, anti-HBc, HBsAg, and HCV/HBV co-infection was 37.1%, 26.6%, 67.7%, 10.7%, and 30.0%, respectively. Two-hundred-twenty-three of 227 (98.2%) participants positive for HCV RNA were aged >40 years. Co-infection was related to sex, age, number of injections, and time from first injection. The rate of spontaneous HCV RNA clearance was 28.2% (89/316), and was related to the number of injections, time from first injection, and HBsAg positivity. However, HBsAg was related to the anti-HBc signal/cut-off ratio rather than to the above parameters. Trend tests demonstrated that the prevalence of anti-HCV, HCV RNA, and anti-HBc was related to the number of injections (P < 0.001), while HBsAg prevalence was not (P = 0.347). Conclusions The prevalence of HCV and HBV infection is likely to be high among individuals older than 40 years in areas of needle sharing, and one-time screening for HCV infection should be offered to these populations.
Related Links	https://bmcpublichealth.biomedcentral.com/counter/pdf/10.1186/s12889-015-1808-0.pdf
Ending Page	7
Page Count	7
Starting Page	1
File Format	HTM / HTML
ISSN	14712458
DOI	10.1186/s12889-015-1808-0
Journal	BMC Public Health
Issue Number	1
Volume Number	15
Language	English
Publisher	BioMed Central
Publisher Date	2015-05-02
Access Restriction	Open
Subject Keyword	Public Health Medicine Epidemiology Biostatistics Vaccine Environmental Health Prevalence Hepatitis C virus Hepatitis B virus Hepatitis Intravenous drug user Medicine/Public Health
Content Type	Text
Resource Type	Article
Subject	Public Health, Environmental and Occupational Health
Journal Impact Factor	3.5/2023
5-Year Journal Impact Factor	3.9/2023

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