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| Content Provider | Springer Nature : BioMed Central |
|---|---|
| Author | Hashemi-Mohammadabad, Nazir Taghavi, Seyed-Abdolvahab Lambert, Nicky Moshtaghi, Raana Bazarganipour, Fatemeh Sharifi, Mahboubeh |
| Abstract | Background According to the Institute of Health Metrics and Evaluation’s Global Health Data Exchange (2023) it is estimated that 5% of all adults will experience depressive disorder. Amongst the general loss of pleasure and interest in everyday activities that are symptoms of low mood, reduced sexual desire and sexual dysfunction can be particularly overlooked. Human sexuality is complex, but finding solutions based on scientific evidence to limit the symptoms of depressive disorder and the iatrogenic impact of antidepressant treatment to improve this outcome is an important step in promoting psychological health and general wellbeing. Objective The present study aimed is to provide scientific evidence to assess the effect of oral probiotic on sexual function in women with depressive disorder treated with Selective Serotonin Reuptake Inhibitors (SSRIs) in an Iranian population. Design This study was a double-blind randomized clinical trial. Eligible women were assigned to lactofem plus SSRIs (n = 58) or SSRIs alone (n = 54). In group A, SSRI antidepressants were prescribed together with Lactofem, and in group B, SSRI antidepressants were prescribed alone. Lactofem including Lactobacillus acidophilus 2 × 109 cfu/g, Bifidobacterium bifidus 2 × 109 cfu/g, Lactobacillus rutri 2 × 109 cfu/g, Lactobacillus fermentum 2 × 109 cfu/g; capsule weight of 500 mg bio-capsule administered orally and daily. The duration of intervention in two groups was two months. All questionnaires were completed by the patients before and after the intervention. The Female Sexual Function Index (FSFI), Hamilton Depression Rating Scale and Larson's Sexual Satisfaction Questionnaire were used to evaluate sexual function, severity of depressive disorder and sexual satisfaction, respectively. Results Based on the results of the present study, there was a statistically significant difference in sexual satisfaction and severity of depressive disorder between the groups before and after the intervention (P < 0.05). Also, our findings showed that after eight weeks, the Lactofem plus SSRIs group showed significant improvement in FSFI domains and total scores compared to SSRIs alone group (P < 0.05). Conclusions The results of the present study show that taking probiotics for eight weeks may improve the severity of depressive disorder, sexual function and sexual satisfaction in depressed women treated with SSRIs. Trial registration ClinicalTrials.govidentifier: IRCT20160524028038N14 (19/12/2022) |
| Related Links | https://bmcpsychiatry.biomedcentral.com/counter/pdf/10.1186/s12888-023-05429-w.pdf |
| Ending Page | 11 |
| Page Count | 11 |
| Starting Page | 1 |
| File Format | HTM / HTML |
| DOI | 10.1186/s12888-023-05429-w |
| Journal | BMC Psychiatry |
| Issue Number | 1 |
| Volume Number | 24 |
| Language | English |
| Publisher | BioMed Central |
| Publisher Date | 2024-01-12 |
| Access Restriction | Open |
| Subject Keyword | Psychiatry Psychotherapy Probiotic Sexual function Depressive disorder Sexual satisfaction |
| Content Type | Text |
| Resource Type | Article |
| Subject | Psychiatry and Mental Health |
| Journal Impact Factor | 3.4/2023 |
| 5-Year Journal Impact Factor | 4.2/2023 |
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