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| Content Provider | Springer Nature : BioMed Central |
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| Author | Bessonova, Leona Velligan, Dawn I. Weiden, Peter J. O’Sullivan, Amy K. Yarlas, Aaron Bayliss, Martha Baranwal, Nishtha Rychlec, Kaitlin Carpenter-Conlin, Julia Doane, Michael J. Sajatovic, Martha |
| Abstract | Background Oral antipsychotic (AP) medications are frequently prescribed to people with bipolar I disorder (BD-I). A cross-sectional online survey examined the experiences of people living with BD-I with a history of recent AP use. Methods Adults with self-reported physician-diagnosed BD-I (N = 200) who received oral APs during the prior year completed a survey on AP-related experiences, including side effects and their perceived burden on social functioning, adherence, and work. Items also assessed preferences for trade-offs (balancing symptom management and side effects) when considering a hypothetical new AP. The perceived impact of specific, prevalent side effects on adherence, work, and preferences for a hypothetical AP were also examined. Analyses were descriptive. Results The survey sample had a mean age of 43.2 (SD = 12.4) years, was 60% female, and 31% nonwhite. Almost all participants (98%) had experienced AP side effects. Common self-reported side effects were feeling drowsy or tired (83%), lack of emotion (79%), anxiety (79%), dry mouth (76%), and weight gain (76%). Weight gain was cited as the most bothersome side effect, rated by most participants (68%) as “very” or “extremely bothersome.” Nearly half of participants (49%) reported that AP side effects negatively impacted their job performance; almost all (92%) reported that side effects – most commonly anxiety and lack of emotion – negatively impacted social relationships (e.g., family or romantic partners). The most commonly-reported reason for stopping AP use was dislike of side effects (48%). Side effects most likely to lead to stopping or taking less of AP treatment included “feeling like a ‘zombie’” (29%), feeling drowsy or tired (25%), and weight gain (24%). When considering a hypothetical new AP, the most common side effects participants wanted to avoid included AP-induced anxiety (50%), weight gain (48%), and “feeling like a ‘zombie’” (47%). Conclusions Side effects of APs were both common and bothersome, and impacted social functioning, adherence, and work. Findings highlight the prevailing unmet need for new APs with more favorable benefit-risk profiles. |
| Related Links | https://bmcpsychiatry.biomedcentral.com/counter/pdf/10.1186/s12888-020-02767-x.pdf |
| Ending Page | 12 |
| Page Count | 12 |
| Starting Page | 1 |
| File Format | HTM / HTML |
| DOI | 10.1186/s12888-020-02767-x |
| Journal | BMC Psychiatry |
| Issue Number | 1 |
| Volume Number | 20 |
| Language | English |
| Publisher | BioMed Central |
| Publisher Date | 2020-07-10 |
| Access Restriction | Open |
| Subject Keyword | Psychiatry Psychotherapy Bipolar I disorder Bipolar disorder Antipsychotic Side effects Adherence Preference |
| Content Type | Text |
| Resource Type | Article |
| Subject | Psychiatry and Mental Health |
| Journal Impact Factor | 3.4/2023 |
| 5-Year Journal Impact Factor | 4.2/2023 |
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