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| Content Provider | Springer Nature : BioMed Central |
|---|---|
| Author | Liotto, Nadia Orsi, Anna Menis, Camilla Piemontese, Pasqua Morlacchi, Laura Condello, Chiara Cristiana Giannì, Maria Lorella Roggero, Paola Mosca, Fabio |
| Abstract | Background A high early protein intake is associated with rapid postnatal weight gain and altered body composition. We aimed to evaluate the safety of a low-protein formula in healthy full-term infants. Methods A randomized controlled trial was conducted. A total of 118 infants were randomized to receive two different protein content formulas (formula A or formula B (protein content: 1.2 vs. 1.7 g/100 mL, respectively)) for the first 4 months of life. Anthropometry and body composition by air displacement plethysmography were assessed at enrolment and at two and 4 months. The reference group comprised 50 healthy, exclusively breastfed, full-term infants. Results Weight gain (g/day) throughout the study was similar between the formula groups (32.5 ± 6.1 vs. 32.8 ± 6.8) and in the reference group (30.4 ± 5.4). The formula groups showed similar body composition but a different fat-free mass content from breastfed infants at two and 4 months. However, the formula A group showed a fat-free mass increase more similar to that of the breastfed infants. The occurrence of gastrointestinal symptoms or adverse events was similar between the formula groups. Conclusions Feeding a low-protein content formula appears to be safe and to promote adequate growth, although determination of the long-term effect on body composition requires further study. Trial registration The present study was retrospectively registered in ClinicalTrials.gov (trial number: NCT03035721 on January 18, 2017). |
| Related Links | https://bmcpediatr.biomedcentral.com/counter/pdf/10.1186/s12887-018-1046-6.pdf |
| Ending Page | 7 |
| Page Count | 7 |
| Starting Page | 1 |
| File Format | HTM / HTML |
| ISSN | 14712431 |
| DOI | 10.1186/s12887-018-1046-6 |
| Journal | BMC Pediatrics |
| Issue Number | 1 |
| Volume Number | 18 |
| Language | English |
| Publisher | BioMed Central |
| Publisher Date | 2018-02-13 |
| Access Restriction | Open |
| Subject Keyword | Pediatrics Internal Medicine Low-protein formula Safety Growth Body composition Full-term infants |
| Content Type | Text |
| Resource Type | Article |
| Subject | Pediatrics, Perinatology and Child Health |
| Journal Impact Factor | 2/2023 |
| 5-Year Journal Impact Factor | 2.4/2023 |
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