NDLI: Dietary fatty acids and endometrial cancer risk within the European Prospective Investigation into Cancer and Nutrition

Content Provider	Springer Nature : BioMed Central
Author	Yammine, S. G. Huybrechts, I. Biessy, C. Dossus, L. Panico, S. Sánchez, M. J. Benetou, V. Turzanski-Fortner, R. Katzke, V. Idahl, A. Skeie, G. Olsen, K. Standahl Tjønneland, A. Halkjaer, J. Colorado-Yohar, S. Heath, A. K. Sonestedt, E. Sartor, H. Schulze, M. B. Palli, D. Crous-Bou, M. Dorronsoro, A. Overvad, K. Gurrea, A. Barricarte Severi, G. Vermeulen, R. C.H. Sandanger, T. M. Travis, R. C. Key, T. Amiano, P. Van Guelpen, B. Johansson, M. Sund, M. Tumino, R. Wareham, N. Sacerdote, C. Krogh, V. Brennan, P. Riboli, E. Weiderpass, E. Gunter, M. J. Chajès, V.
Abstract	Background Diet may impact important risk factors for endometrial cancer such as obesity and inflammation. However, evidence on the role of specific dietary factors is limited. We investigated associations between dietary fatty acids and endometrial cancer risk in the European Prospective Investigation into Cancer and Nutrition (EPIC). Methods This analysis includes 1,886 incident endometrial cancer cases and 297,432 non-cases. All participants were followed up for a mean of 8.8 years. Multivariable Cox proportional hazard models were used to estimate hazard ratios (HR) and 95% confidence intervals (CI) of endometrial cancer across quintiles of individual fatty acids estimated from various food sources quantified through food frequency questionnaires in the entire EPIC cohort. The false discovery rate (q-values) was computed to control for multiple comparisons. Results Consumption of n-6 γ-linolenic acid was inversely associated with endometrial cancer risk (HR comparing 5th with 1st quintileQ5−Q1=0.77, 95% CI = 0.64; 0.92, ptrend=0.01, q-value = 0.15). This association was mainly driven by γ-linolenic acid derived from plant sources (HRper unit increment=0.94, 95%CI= (0.90;0.98), p = 0.01) but not from animal sources (HRper unit increment= 1.00, 95%CI = (0.92; 1.07), p = 0.92). In addition, an inverse association was found between consumption of n-3 α-linolenic acid from vegetable sources and endometrial cancer risk (HRper unit increment= 0.93, 95%CI = (0.87; 0.99), p = 0.04). No significant association was found between any other fatty acids (individual or grouped) and endometrial cancer risk. Conclusion Our results suggest that higher consumption of γ-linolenic acid and α-linoleic acid from plant sources may be associated with lower risk of endometrial cancer.
Related Links	https://bmccancer.biomedcentral.com/counter/pdf/10.1186/s12885-023-10611-0.pdf
Ending Page	12
Page Count	12
Starting Page	1
File Format	HTM / HTML
ISSN	14712407
DOI	10.1186/s12885-023-10611-0
Journal	BMC Cancer
Issue Number	1
Volume Number	23
Language	English
Publisher	BioMed Central
Publisher Date	2023-02-16
Access Restriction	Open
Subject Keyword	Cancer Research Oncology Surgical Oncology Health Promotion and Disease Prevention Biomedicine Medicine Public Health Fatty acids Endometrial cancer Epidemiology Diet Medicine/Public Health
Content Type	Text
Resource Type	Article
Subject	Cancer Research Oncology Genetics
Journal Impact Factor	3.4/2023
5-Year Journal Impact Factor	3.8/2023

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