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| Content Provider | Springer Nature : BioMed Central |
|---|---|
| Author | Gao, Zhou Xue, Min Wang, Zhibiao |
| Abstract | Objective Placental accreta spectrum (PAS) is a collective term for a range of pregnancy complications caused by abnormal placental implantation, posing a threat to the lives of both the mother and the fetus. This study aimed to screen for placental marker metabolites of PAS and assess the effect of L-Arginine on trophoblast invasion. Methods Placental tissues were collected from a total of 15 pregnant women, including 10 women diagnosed with PAS and 5 women with normal pregnancies. Histological staining was used to characterize pathological changes in the placenta. The changes in endogenous placental metabolites by LC-MS/MS. Subsequently, the role of marker metabolite L-Arginine on HTR-8/Svneo invasion was explored, and protein transcription and expression levels of GPRC6A/PI3K/AKT/MMP2/MMP9 were determined by RT-qPCR and western blot. Results The placentas of PAS patients were mostly infiltrative invasion, with active proliferation and inhibited apoptosis of trophoblast cells. By LC-MS/MS, we identified 13 significantly different metabolites between healthy and PAS pregnant women’s placenta tissue. Among them, placental concentrations of L-Arginine were significantly higher in PAS pregnant women than in controls. In vitro, L-Arginine promoted the proliferation and migration of HTR8/SVneo cells and upregulated the transcription and expression of proteins related to the GPRC6A/PI3K/AKT pathway. Conclusions Our study demonstrates that L-Arginine may promote trophoblast invasion and migration in placental implantation by upregulating the GPRC6A/PI3K/AKT pathway. This provides a new basis for screening appropriate metabolic markers for PAS, thus contributing to the prevention and treatment of PAS. |
| Related Links | https://bmcpregnancychildbirth.biomedcentral.com/counter/pdf/10.1186/s12884-025-07475-6.pdf |
| Ending Page | 13 |
| Page Count | 13 |
| Starting Page | 1 |
| File Format | HTM / HTML |
| ISSN | 14712393 |
| DOI | 10.1186/s12884-025-07475-6 |
| Journal | BMC Pregnancy and Childbirth |
| Issue Number | 1 |
| Volume Number | 25 |
| Language | English |
| Publisher | BioMed Central |
| Publisher Date | 2025-04-07 |
| Access Restriction | Open |
| Subject Keyword | Reproductive Medicine Maternal and Child Health Gynecology Placenta accreta spectrum L-Arginine LC-MS/MS Metabonomics HTR-8/Svneo GPRC6A/PI3K/AKT pathway |
| Content Type | Text |
| Resource Type | Article |
| Subject | Obstetrics and Gynecology |
| Journal Impact Factor | 2.8/2023 |
| 5-Year Journal Impact Factor | 3.4/2023 |
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