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| Content Provider | Springer Nature : BioMed Central |
|---|---|
| Author | Lambrecht, Stijn Speeckaert, Marijn Oyaert, Matthijs |
| Abstract | Introduction Clinical laboratories play an important role in the diagnosis and monitoring of chronic kidney disease (CKD). Our aim was to evaluate the performance of qualitative and semi-quantitative albumin-to-creatinine ratio (ACR) and protein-to-creatinine ratio (PCR) test strip results as screening tools for albuminuria in multiple representative patient cohorts. Materials and methods ACR and PCR were evaluated in both cross-sectional (n = 940) and validation (n = 927) patient cohorts. Semi-quantitative urinary ACR and PCR were performed using a UC-3500 instrument (Sysmex, Kobe, Japan). The diagnostic performance of semi-quantitative ACR and PCR was determined using quantitative ACR and PCR as reference method. Results In the cross-sectional cohort, a sensitivity and specificity of 78.1% and 93.3%, respectively, were obtained for semi-quantitative ACR at a cut-off of 30 mg/g creatinine, with an overall agreement of > 90% between both methods. The sensitivity and specificity increased in the target population (validation cohort) to 89.9% and 92.1%, respectively. In contrast, the sensitivities of qualitative protein concentration (78.6%) and semi-quantitative PCR (69.8%) were lower. Conclusion The results confirm that urine test strip readouts are a valuable screening tool for CKD in low-risk individuals. ACR should be the preferred criterion for reflex testing when using a urine test strip for screening CKD. |
| Related Links | https://bmcnephrol.biomedcentral.com/counter/pdf/10.1186/s12882-025-04048-9.pdf |
| Ending Page | 8 |
| Page Count | 8 |
| Starting Page | 1 |
| File Format | HTM / HTML |
| ISSN | 14712369 |
| DOI | 10.1186/s12882-025-04048-9 |
| Journal | BMC Nephrology |
| Issue Number | 1 |
| Volume Number | 26 |
| Language | English |
| Publisher | BioMed Central |
| Publisher Date | 2025-03-10 |
| Access Restriction | Open |
| Subject Keyword | Nephrology Internal Medicine Albuminuria Automated Proteinuria Urinalysis Urinary test strip analysis |
| Content Type | Text |
| Resource Type | Article |
| Subject | Nephrology |
| Journal Impact Factor | 2.2/2023 |
| 5-Year Journal Impact Factor | 2.6/2023 |
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