NDLI: Paricalcitol supplementation during the first year after kidney transplantation does not affect calcification propensity score

Content Provider	Springer Nature : BioMed Central
Author	Ussif, Amin Pihlstrøm, Hege Pasch, Andreas Holdaas, Hallvard Hartmann, Anders Smerud, Knut Åsberg, Anders
Abstract	Background Cardiovascular complications are common in kidney transplant patients and calcification propensity of blood, measured as T50, is associated with cardiovascular outcomes. Paricalcitol supplementation affects calcium/phosphate homeostasis and may affect calcification propensity. To assess this hypothesis we measured T50 in kidney transplant recipients participating in a randomized study comparing paricalcitol versus no treatment during the first year after kidney transplantation. Methods Stored serum samples from 76 kidney transplant recipients (paricalcitol n = 37, no treatment n = 39) were analyzed. Analyses were performed at inclusion (8 weeks after transplantation) and repeated one year after transplantation. Results There were no statistically significant differences in T50 between the paricalcitol and placebo groups, neither at baseline (p = 0.56) nor at 1 year (p = 0.61). Also, there were no significant changes in T50 over time in either group or when pooling all data (p < 0.20). In multivariate regression analysis, out of 16 potentially relevant covariates, comprising clinical and biochemical parameters, only plasma PTH and T50 at baseline were significantly correlated to T50 after one year. (p < 0.03 and p < 0.01, respectively). Conclusions Calcium propensity measured as T50 score remained unchanged with paricalcitol treatment in kidney transplant recipients, and was not changed over time during the study period of one year. Trial registration ClinicalTrials.gov, NCT01694160 , registered 23 September 2012.
Related Links	https://bmcnephrol.biomedcentral.com/counter/pdf/10.1186/s12882-018-1000-8.pdf
Ending Page	5
Page Count	5
Starting Page	1
File Format	HTM / HTML
ISSN	14712369
DOI	10.1186/s12882-018-1000-8
Journal	BMC Nephrology
Issue Number	1
Volume Number	19
Language	English
Publisher	BioMed Central
Publisher Date	2018-08-22
Access Restriction	Open
Subject Keyword	Nephrology Internal Medicine Paricalcitol Calcification propensity score Randomized controlled trial Renal transplantation
Content Type	Text
Resource Type	Article
Subject	Nephrology
Journal Impact Factor	2.2/2023
5-Year Journal Impact Factor	2.6/2023

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