NDLI: Haemolytic uraemic syndrome - a rare case report of bloody diarrhoea in adults

Content Provider	Springer Nature : BioMed Central
Author	Radhakrishnan, Shiva Thambiah Ruban, Aruchuna Uthayakumar, Aarthy Kanmany Cohen, Patrizia Levy, Jeremy Teare, Julian
Abstract	Background Haemolytic uraemic syndrome is a rarely seen in adults often leading to critical illness. This case highlights how difficult it can be to establish a diagnosis and treat when a patient presents with bloody diarrhoea. Case presentation A 17-year-old Iraqi man presented to the emergency department with abdominal pain and bloody diarrhoea. He was initially treated as acute appendicitis, undergoing an appendectomy but following a recurrence in his symptoms a colonoscopy was performed. A diagnosis of shiga toxin-producing Escherichia coli leading to HUS was suspected following histology obtained at colonoscopy and this was confirmed on antibody testing. Despite intravenous fluids and supportive therapy the patient’s symptoms and condition deteriorated. He developed seizures and acute renal failure requiring intubation and plasma exchange in the intensive care setting. He eventually required treatment with ecluzimab therapy; a monoclonal antibody and subsequently made a full recovery. Conclusions Haemolytic uraemic syndrome is a triad of progressive renal failure, thrombocytopenia and haemolytic anaemia which is a condition rarely seen in adults. It is usually associated with an E. coli infection and supportive therapy remains the mainstay of treatment.
Related Links	https://bmcgastroenterol.biomedcentral.com/counter/pdf/10.1186/s12876-019-1071-4.pdf
Ending Page	4
Page Count	4
Starting Page	1
File Format	HTM / HTML
DOI	10.1186/s12876-019-1071-4
Journal	BMC Gastroenterology
Issue Number	1
Volume Number	19
Language	English
Publisher	BioMed Central
Publisher Date	2019-08-28
Access Restriction	Open
Subject Keyword	Gastroenterology Internal Medicine Hepatology E.coli 0157 Bloody diarrhoea Haemolytic uraemic syndrome Plasma exchange Shiga-toxin
Content Type	Text
Resource Type	Case study
Subject	Gastroenterology
Journal Impact Factor	2.5/2023
5-Year Journal Impact Factor	2.7/2023

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