NDLI: Nebulized dexmedetomidine in the treatment of obstetric post-dural puncture headache: two case reports

Content Provider	Springer Nature : BioMed Central
Author	Thomas, Jeffrey Soloniuk, Leonard J. Mehdizadeh, Chris Cheng, Peter Sinha, Ashish
Abstract	Post-dural puncture headache (PDPH) is a debilitating complication of neuraxial anesthesia, particularly prevalent in obstetric patients, usually characterized by a postural headache. PDPH is hypothesized to result from cerebrospinal fluid leakage through a dural puncture, triggering symptoms like neck stiffness and subjective hearing changes. While conservative measures are common for treatment, more refractory cases may require invasive interventions such as an epidural blood patch (EBP). Recent studies have shown promise in using nebulized dexmedetomidine (nDEX) for PDPH, offering a non-invasive alternative to EBP. Two case presentations illustrate the efficacy of nDEX in resolving PDPH symptoms rapidly and completely. These cases underscore the need for exploring novel therapeutic options, especially in obstetric patients where safe and prompt relief is essential for maternal and newborn well-being. While the EBP remains the gold standard, its limitations of accessibility and invasiveness highlight the significance of investigating alternatives like nDEX.
Related Links	https://bmcanesthesiol.biomedcentral.com/counter/pdf/10.1186/s12871-025-02896-4.pdf
Ending Page	4
Page Count	4
Starting Page	1
File Format	HTM / HTML
ISSN	14712253
DOI	10.1186/s12871-025-02896-4
Journal	BMC Anesthesiology
Issue Number	1
Volume Number	25
Language	English
Publisher	BioMed Central
Publisher Date	2025-01-11
Access Restriction	Open
Subject Keyword	Anesthesiology Internal Medicine Emergency Medicine Intensive Critical Care Medicine Obstetric post-dural puncture headache (PDPH) Obstetric anesthesia Neuraxial anesthesia Dexmedetomidine Cesarean delivery Case report
Content Type	Text
Resource Type	Case study
Subject	Anesthesiology and Pain Medicine
Journal Impact Factor	2.3/2023
5-Year Journal Impact Factor	2.6/2023

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