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| Content Provider | Springer Nature : BioMed Central |
|---|---|
| Author | Li, Yuxuan Jie, Yang Wang, Xiaofei Lu, Jing |
| Abstract | Background Obesity is correlated with worse drug responses and high disease activity in patients with rheumatoid arthritis (RA). Interleukin (IL)-35 is a novel anti-inflammatory cytokine that mainly produced by regulatory T (Treg). This study was performed to analyze whether IL-35 was correlated with obesity in RA and investigate the correlation between other Th1/Th2/Th17-related cytokines and obesity in RA. Results The serum IL-35 level was analyzed in RA (n = 81) and healthy donors (n = 53) by ELISA assay, and was compared between three groups (body mass index (BMI) < 18.5,≥18.5 to 25, > 25). Serum cytokines including IL-2, IL-4, IL-10, IL-17, INF-γ, TNF-α levels were measured using Flowcytometry assay. Clinical information was extracted from medical records. Serum IL-35 level in overweight patients were significantly decreased than those in lean patients. Furthermore, Th1/Th2/Th17-related cytokines from overweight patients with RA showed the characteristic immunological features. Serum IL-6, IL-17 and TNF-α levels were positively correlated with BMI. However, serum IL-2, IL-4, IL-10 and IFN-γ concentrations were not correlated with BMI. Conclusions Quantitative changes in serum IL-35 level were characteristic in overweight patients with RA. These findings indicate that IL-35 plays an important role in the development of RA and may prove to be a potential biomarker of active RA. |
| Related Links | https://bmcimmunol.biomedcentral.com/counter/pdf/10.1186/s12865-021-00431-x.pdf |
| Ending Page | 8 |
| Page Count | 8 |
| Starting Page | 1 |
| File Format | HTM / HTML |
| ISSN | 14712172 |
| DOI | 10.1186/s12865-021-00431-x |
| Journal | BMC Immunology |
| Issue Number | 1 |
| Volume Number | 22 |
| Language | English |
| Publisher | BioMed Central |
| Publisher Date | 2021-06-27 |
| Access Restriction | Open |
| Subject Keyword | Immunology Allergology Vaccine Cytokines and Growth Factors Interlukin-35 Th1/Th2/Th17 cytokines Rheumatoid arthritis Obesity |
| Content Type | Text |
| Resource Type | Article |
| Subject | Immunology |
| Journal Impact Factor | 2.9/2023 |
| 5-Year Journal Impact Factor | 3.3/2023 |
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