NDLI: A genome-scale metabolic model of potato late blight suggests a photosynthesis suppression mechanism

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A genome-scale metabolic model of potato late blight suggests a photosynthesis suppression mechanism

Content Provider	Springer Nature : BioMed Central
Author	Botero, Kelly Restrepo, Silvia Pinzón, Andres
Abstract	Background Phytophthora infestans is a plant pathogen that causes an important plant disease known as late blight in potato plants (Solanum tuberosum) and several other solanaceous hosts. This disease is the main factor affecting potato crop production worldwide. In spite of the importance of the disease, the molecular mechanisms underlying the compatibility between the pathogen and its hosts are still unknown. Results To explain the metabolic response of late blight, specifically photosynthesis inhibition in infected plants, we reconstructed a genome-scale metabolic network of the S. tuberosum leaf, PstM1. This metabolic network simulates the effect of this disease in the leaf metabolism. PstM1 accounts for 2751 genes, 1113 metabolic functions, 1773 gene-protein-reaction associations and 1938 metabolites involved in 2072 reactions. The optimization of the model for biomass synthesis maximization in three infection time points suggested a suppression of the photosynthetic capacity related to the decrease of metabolic flux in light reactions and carbon fixation reactions. In addition, a variation pattern in the flux of carboxylation to oxygenation reactions catalyzed by RuBisCO was also identified, likely to be associated to a defense response in the compatible interaction between P. infestans and S. tuberosum. Conclusions In this work, we introduced simultaneously the first metabolic network of S. tuberosum and the first genome-scale metabolic model of the compatible interaction of a plant with P. infestans.
Related Links	https://bmcgenomics.biomedcentral.com/counter/pdf/10.1186/s12864-018-5192-x.pdf
Ending Page	44
Page Count	14
Starting Page	31
File Format	HTM / HTML
ISSN	14712164
DOI	10.1186/s12864-018-5192-x
Journal	BMC Genomics
Issue Number	8
Volume Number	19
Language	English
Publisher	BioMed Central
Publisher Date	2018-12-11
Access Restriction	Open
Subject Keyword	Life Sciences Microarrays Proteomics Animal Genetics and Genomics Microbial Genetics and Genomics Plant Genetics and Genomics Phytophthora infestans Solanum tuberosum Compatible interaction Systems biology Metabolic reconstruction Flux balance analysis
Content Type	Text
Resource Type	Article
Subject	Biotechnology Genetics
Journal Impact Factor	3.5/2023
5-Year Journal Impact Factor	4.1/2023

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