| Content Provider | Springer Nature : BioMed Central |
|---|---|
| Author | Rubins, Kathleen H Hensley, Lisa E Wahl-Jensen, Victoria Daddario DiCaprio, Kathleen M Young, Howard A Reed, Douglas S Jahrling, Peter B Brown, Patrick O Relman, David A Geisbert, Thomas W |
| Abstract | Background Infection with Ebola virus (EBOV) causes a fulminant and often fatal hemorrhagic fever. In order to improve our understanding of EBOV pathogenesis and EBOV-host interactions, we examined the molecular features of EBOV infection in vivo. Results Using high-density cDNA microarrays, we analyzed genome-wide host expression patterns in sequential blood samples from nonhuman primates infected with EBOV. The temporal program of gene expression was strikingly similar between animals. Of particular interest were features of the data that reflect the interferon response, cytokine signaling, and apoptosis. Transcript levels for tumor necrosis factor-α converting enzyme (TACE)/α-disintegrin and metalloproteinase (ADAM)-17 increased during days 4 to 6 after infection. In addition, the serum concentration of cleaved Ebola glycoprotein (GP2 delta) was elevated in late-stage EBOV infected animals. Of note, we were able to detect changes in gene expression of more than 300 genes before symptoms appeared. Conclusion These results provide the first genome-wide ex vivo analysis of the host response to systemic filovirus infection and disease. These data may elucidate mechanisms of viral pathogenesis and host defense, and may suggest targets for diagnostic and therapeutic development. |
| Related Links | https://genomebiology.biomedcentral.com/counter/pdf/10.1186/gb-2007-8-8-r174.pdf |
| Ending Page | 14 |
| Page Count | 14 |
| Starting Page | 1 |
| File Format | HTM / HTML |
| DOI | 10.1186/gb-2007-8-8-r174 |
| Journal | Genome Biology |
| Issue Number | 8 |
| Volume Number | 8 |
| Language | English |
| Publisher | BioMed Central |
| Publisher Date | 2007-08-28 |
| Access Restriction | Open |
| Subject Keyword | Animal Genetics and Genomics Human Genetics Plant Genetics and Genomics Microbial Genetics and Genomics Bioinformatics Evolutionary Biology Additional Data File Cynomolgus Macaque Nonhuman Primate Model Mixed Cell Population EBOV Infection |
| Content Type | Text |
| Resource Type | Article |
| Subject | Biotechnology Genetics |
| Journal Impact Factor | 10.1/2023 |
| 5-Year Journal Impact Factor | 16.5/2023 |
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