NDLI: The dominance of the population by a selected few: power-law behaviour applies to a wide variety of genomic properties

Content Provider	Springer Nature : BioMed Central
Author	Luscombe, Nicholas M Qian, Jiang Zhang, Zhaolei Johnson, Ted Gerstein, Mark
Abstract	Background The sequencing of genomes provides us with an inventory of the 'molecular parts' in nature, such as protein families and folds, and their functions in living organisms. Through the analysis of such inventories, it has been shown that different genomes have very different usage of parts; for example, the common folds in the worm are very different from those in Escherichia coli. Results Despite these differences, we find that the genomic occurrence of generalized parts follows a well-known mathematical framework called the power law, with a few parts occurring many times and most occurring only a few times. This observation is true in a wide variety of genomic contexts. Earlier studies found power laws in a few specific cases, such as the occurrence of protein families. Here, we find many further cases of power-law behavior, for example in the occurrence of pseudogenes and in levels of gene expression. We show comprehensively that this behavior applies across many different genomes, for many different types of parts (DNA words, InterPro families, protein superfamilies and folds, pseudogene families and pseudomotifs), and for the many disparate attributes associated with these parts (their functions, interactions and expression levels). Conclusions Power-law behavior provides a concise mathematical description of an important biological feature: the sheer dominance of a few members over the overall population. We present this behavior in a unified framework and propose that all these observations are connected to an underlying DNA duplication process as genomes evolved to their current state.
Related Links	https://genomebiology.biomedcentral.com/counter/pdf/10.1186/gb-2002-3-8-research0040.pdf
Ending Page	7
Page Count	7
Starting Page	1
File Format	HTM / HTML
DOI	10.1186/gb-2002-3-8-research0040
Journal	Genome Biology
Issue Number	8
Volume Number	3
Language	English
Publisher	BioMed Central
Publisher Date	2002-07-25
Access Restriction	Open
Subject Keyword	Animal Genetics and Genomics Human Genetics Plant Genetics and Genomics Microbial Genetics and Genomics Bioinformatics Evolutionary Biology Additional Data File Genomic Property Genomic Biology Interdomain Interaction Duplicative Process
Content Type	Text
Resource Type	Article
Subject	Biotechnology Genetics
Journal Impact Factor	10.1/2023
5-Year Journal Impact Factor	16.5/2023

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1	Ministry of Education (GoI), Department of Higher Education	Sanctioning Authority	https://www.education.gov.in/ict-initiatives
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