NDLI: Influence of dextran-70 on systemic inflammatory response and myocardial ischaemia-reperfusion following cardiac operations

Content Provider	Springer Nature : BioMed Central
Author	Gombocz, Károly Beledi, Ágnes Alotti, Nasri Kecskés, Gábor Gábor, Valéria Bogár, Lajos Kőszegi, Tamás Garai, János
Abstract	Introduction Experimental studies have demonstrated that dextran-70 reduces the leukocyte–endothelium interaction, but clinical evidence is still lacking. Our objective was to justify the anti-inflammatory effect of dextran-70 following cardiac operations. Methods Forty patients undergoing coronary bypass surgery (n = 32) or aortic valve replacement (n = 8) were enrolled in this prospective, randomized, double-blind study. Two groups were formed. In group A (n = 20), dextran-70 infusion was administered at a dose of 7.5 ml/kg before the initiation of cardiopulmonary bypass and at a dose of 12.5 ml/kg after the cessation of cardiopulmonary bypass. Group B served as a control with identical amounts of gelatin infusion (n = 20). The plasma concentration of procalcitonin, C-reactive protein, IL 6, IL 6r, IL 8, IL 10, soluble endothelial leukocyte adhesion molecule-1, soluble intercellular adhesion molecule-1, cardiac troponin-I and various haemodynamic parameters were measured in the perioperative period. Multivariate methods were used for statistical analysis. Results In group A, lower peak (median) plasma levels of procalcitonin (0.2 versus 1.4, p < 0.001), IL 8 (5.6 versus 94.8, p < 0.001), IL 10 (47.2 versus 209.7, p = 0.001), endothelial leukocyte adhesion molecule-1 (88.5 versus 130.6, p = 0.033), intercellular adhesion molecule-1 (806.7 versus 1,375.7, P = 0.001) and troponin-I (0.22 versus 0.66, p = 0.018) were found. There was no significant difference in IL 6, IL-6r and C-reactive protein values between groups. Higher figures of the cardiac index (p = 0.010) along with reduced systemic vascular resistance (p = 0.005) were noted in group A. Conclusion Our investigation demonstrated that the use of dextran-70 reduces the systemic inflammatory response and cardiac troponin-I release following cardiac operation. Trial registration number ISRCTN38289094.
Related Links	https://ccforum.biomedcentral.com/counter/pdf/10.1186/cc6095.pdf
Ending Page	10
Page Count	10
Starting Page	1
File Format	HTM / HTML
ISSN	13648535
DOI	10.1186/cc6095
Journal	Critical Care
Issue Number	4
Volume Number	11
Language	English
Publisher	BioMed Central
Publisher Date	2007-08-14
Access Restriction	Open
Subject Keyword	Intensive Critical Care Medicine Emergency Medicine Coronary Artery Bypass Grafting Procalcitonin Stroke Volume Variation Stroke Volume Index Systemic Vascular Resistance Index
Content Type	Text
Resource Type	Article
Subject	Critical Care and Intensive Care Medicine
Journal Impact Factor	8.8/2023
5-Year Journal Impact Factor	10.4/2023

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