| Content Provider | Springer Nature : BioMed Central |
|---|---|
| Author | Naka, Toshio Jones, Daryl Baldwin, Ian Fealy, Nigel Bates, Samantha Goehl, Hermann Morgera, Stanislao Neumayer, Hans H Bellomo, Rinaldo |
| Abstract | Objective To test the ability of a novel super high-flux (SHF) membrane with a larger pore size to clear myoglobin from serum. Setting The intensive care unit of a university teaching hospital. Subject A patient with serotonin syndrome complicated by severe rhabodomyolysis and oliguric acute renal failure Method Initially continuous veno-venous hemofiltration was performed at 2 l/hour ultrafiltration (UF) with a standard polysulphone 1.4 m2 membrane (cutoff point, 20 kDa), followed by continuous veno-venous hemofiltration with a SHF membrane (cutoff point, 100 kDa) at 2 l/hour UF, then at 3 l/hour UF and then at 4 l/hour UF, in an attempt to clear myoglobin. Results The myoglobin concentration in the ultrafiltrate at 2 l/hour exchange was at least five times greater with the SHF membrane than with the conventional membrane (>100,000 μg/l versus 23,003 μg/l). The sieving coefficients with the SHF membrane at 3 l/hour UF and 4 l/hour UF were 72.2% and 68.8%, respectively. The amount of myoglobin removed with the conventional membrane was 1.1 g/day compared with 4.4–5.1 g/day for the SHF membrane. The SHF membrane achieved a clearance of up to 56.4 l/day, and achieved a reduction in serum myoglobin concentration from >100,000 μg/l to 16,542 μg/l in 48 hours. Conclusions SHF hemofiltration achieved a much greater clearance of myoglobin than conventional hemofiltration, and it may provide a potential modality for the treatment of myoglobinuric acute renal failure. |
| Related Links | https://ccforum.biomedcentral.com/counter/pdf/10.1186/cc3034.pdf |
| Ending Page | 6 |
| Page Count | 6 |
| Starting Page | 1 |
| File Format | HTM / HTML |
| ISSN | 13648535 |
| DOI | 10.1186/cc3034 |
| Journal | Critical Care |
| Issue Number | 2 |
| Volume Number | 9 |
| Language | English |
| Publisher | BioMed Central |
| Publisher Date | 2005-01-21 |
| Access Restriction | Open |
| Subject Keyword | Intensive Critical Care Medicine Emergency Medicine Anorexia Nervosa Renal Replacement Therapy Continuous Renal Replacement Therapy Moclobemide Serotonin Syndrome |
| Content Type | Text |
| Resource Type | Article |
| Subject | Critical Care and Intensive Care Medicine |
| Journal Impact Factor | 8.8/2023 |
| 5-Year Journal Impact Factor | 10.4/2023 |
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