NDLI: Effects of intravenous furosemide on mucociliary transport and rheological properties of patients under mechanical ventilation

Content Provider	Springer Nature : BioMed Central
Author	Kondo, Cláudia Seiko Macchionne, Mariângela Nakagawa, Naomi Kondo de Carvalho, Carlos Roberto Ribeiro King, Malcolm Saldiva, Paulo Hilário Nascimento Lorenzi-Filho, Geraldo
Abstract	The use of intravenous (IV) furosemide is common practice in patients under mechanical ventilation (MV), but its effects on respiratory mucus are largely unknown. Furosemide can affect respiratory mucus either directly through inhibition of the NaK(Cl)2 co-transporter on the basolateral surface of airway epithelium or indirectly through increased diuresis and dehydration. We investigated the physical properties and transportability of respiratory mucus obtained from 26 patients under MV distributed in two groups, furosemide (n = 12) and control (n = 14). Mucus collection was done at 0, 1, 2, 3 and 4 hours. The rheological properties of mucus were studied with a microrheometer, and in vitro mucociliary transport (MCT) (frog palate), contact angle (CA) and cough clearance (CC) (simulated cough machine) were measured. After the administration of furosemide, MCT decreased by 17 ± 19%, 24 ± 11%, 18 ± 16% and 18 ± 13% at 1, 2, 3 and 4 hours respectively, P < 0.001 compared with control. In contrast, no significant changes were observed in the control group. The remaining parameters did not change significantly in either group. Our results support the hypothesis that IV furosemide might acutely impair MCT in patients under MV.
Related Links	https://ccforum.biomedcentral.com/counter/pdf/10.1186/cc1458.pdf
Ending Page	7
Page Count	7
Starting Page	1
File Format	HTM / HTML
ISSN	13648535
DOI	10.1186/cc1458
Journal	Critical Care
Issue Number	1
Volume Number	6
Language	English
Publisher	BioMed Central
Publisher Date	2001-11-19
Access Restriction	Open
Subject Keyword	Intensive Critical Care Medicine Emergency Medicine furosemide mechanical ventilation mucociliary transport mucus rheology
Content Type	Text
Resource Type	Article
Subject	Critical Care and Intensive Care Medicine
Journal Impact Factor	8.8/2023
5-Year Journal Impact Factor	10.4/2023

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