NDLI: HMGB1 as a drug target in staphylococcal pneumonia

Content Provider	Springer Nature : BioMed Central
Author	Fink, Mitchell P
Abstract	High mobility group box (HMGB)1 is a small DNA-binding protein. In the nucleus, HMGB1 plays a role in gene expression and DNA replication. When it is released or secreted into the extracellular milieu, HMGB1 functions as a pro-inflammatory cytokine-like mediator. Recently reported data support the view that treatment with a neutralizing anti-HMGB1 antibody ameliorated pulmonary damage in a murine model of pneumonia caused by a pathogenic strain of Staphylococcus aureus. These findings suggest that HMGB1 may be an important drug target as scientists, clinical investigators and pharmaceutical companies seek to develop better agents for the treatment of staphylococcal pneumonia. Unfortunately, however, encouraging results from murine models of human disease often fail to translate into positive findings in clinical trials. Thus, before moving from pre-clinical into clinical studies, it may be prudent to validate and extend the recent experimental findings by carrying out additional studies, using a large animal model of pneumonia.
Related Links	https://ccforum.biomedcentral.com/counter/pdf/10.1186/cc13810.pdf
Ending Page	3
Page Count	3
Starting Page	1
File Format	HTM / HTML
ISSN	13648535
DOI	10.1186/cc13810
Journal	Critical Care
Issue Number	2
Volume Number	18
Language	English
Publisher	BioMed Central
Publisher Date	2014-03-31
Access Restriction	Open
Subject Keyword	Intensive Critical Care Medicine Emergency Medicine Hyaluronic Acid Acute Respiratory Distress Syndrome Staphylococcal Pneumonia Endotoxemic Mouse Extracellular HMGB1
Content Type	Text
Subject	Critical Care and Intensive Care Medicine
Journal Impact Factor	8.8/2023
5-Year Journal Impact Factor	10.4/2023

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