NDLI: Risk factors for the development of acute lung injury in patients with infectious pneumonia

Content Provider	Springer Nature : BioMed Central
Author	Kojicic, Marija Li, Guangxi Hanson, Andrew C Lee, Kun-Moo Thakur, Lokendra Vedre, Jayanth Ahmed, Adil Baddour, Larry M Ryu, Jay H Gajic, Ognjen
Abstract	Introduction Although pneumonia has been identified as the single most common risk factor for acute lung injury (ALI), we have a limited knowledge as to why ALI develops in some patients with pneumonia and not in others. The objective of this study was to determine frequency, risk factors, and outcome of ALI in patients with infectious pneumonia. Methods A retrospective cohort study of adult patients with microbiologically positive pneumonia, hospitalized at two Mayo Clinic Rochester hospitals between January 1, 2005, and December 31, 2007. In a subsequent nested case-control analysis, we evaluated the differences in prehospital and intrahospital exposures between patients with and without ALI/acute respiratory distress syndrome (ARDS) matched by specific pathogen, isolation site, gender, and closest age in a 1:1 manner. Results The s tudy included 596 patients; 365 (61.2%) were men. The median age was 65 (IQR, 53 to 75) years. In total, 171 patients (28.7%) were diagnosed with ALI. The occurrence of ALI was less frequent in bacterial (n = 99 of 412, 24%) compared with viral (n = 19 of 55, 35%), fungal (n = 39 of 95, 41%), and mixed isolates pneumonias (n = 14 of 34, 41%; P = 0.002). After adjusting for baseline severity of illness and comorbidities, patients in whom ALI developed had a markedly increased risk of hospital death (ORadj 9.7; 95% CI, 6.0 to 15.9). In a nested case-control study, presence of shock (OR, 8.9; 95% CI, 2.8 to 45.9), inappropriate initial antimicrobial treatment (OR, 3.2; 95% CI, 1.3 to 8.5), and transfusions (OR, 4.8; 95% CI, 1.5 to 19.6) independently predicted ALI development. Conclusions The development of ALI among patients hospitalized with infectious pneumonia varied among pulmonary pathogens and was associated with increased mortality. Inappropriate initial antimicrobial treatment and transfusion predict the development of ALI independent of pathogen.
Related Links	https://ccforum.biomedcentral.com/counter/pdf/10.1186/cc11247.pdf
Ending Page	9
Page Count	9
Starting Page	1
File Format	HTM / HTML
ISSN	13648535
DOI	10.1186/cc11247
Journal	Critical Care
Issue Number	2
Volume Number	16
Language	English
Publisher	BioMed Central
Publisher Date	2012-03-14
Access Restriction	Open
Subject Keyword	Intensive Critical Care Medicine Emergency Medicine Pneumonia Respiratory Syncytial Virus Acute Lung Injury Specific Pathogen Pneumonia Severity Index
Content Type	Text
Resource Type	Article
Subject	Critical Care and Intensive Care Medicine
Journal Impact Factor	8.8/2023
5-Year Journal Impact Factor	10.4/2023

Sl.	Authority	Responsibilities	Communication Details
1	Ministry of Education (GoI), Department of Higher Education	Sanctioning Authority	https://www.education.gov.in/ict-initiatives
2	Indian Institute of Technology Kharagpur	Host Institute of the Project: The host institute of the project is responsible for providing infrastructure support and hosting the project	https://www.iitkgp.ac.in
3	National Digital Library of India Office, Indian Institute of Technology Kharagpur	The administrative and infrastructural headquarters of the project	Dr. B. Sutradhar bsutra@ndl.gov.in
4	Project PI / Joint PI	Principal Investigator and Joint Principal Investigators of the project	Dr. B. Sutradhar bsutra@ndl.gov.in Prof. Saswat Chakrabarti will be added soon
5	Website/Portal (Helpdesk)	Queries regarding NDLI and its services	support@ndl.gov.in
6	Contents and Copyright Issues	Queries related to content curation and copyright issues	content@ndl.gov.in
7	National Digital Library of India Club (NDLI Club)	Queries related to NDLI Club formation, support, user awareness program, seminar/symposium, collaboration, social media, promotion, and outreach	clubsupport@ndl.gov.in
8	Digital Preservation Centre (DPC)	Assistance with digitizing and archiving copyright-free printed books	dpc@ndl.gov.in
9	IDR Setup or Support	Queries related to establishment and support of Institutional Digital Repository (IDR) and IDR workshops	idr@ndl.gov.in

Risk factors for the development of acute lung injury in patients with infectious pneumonia

Year in review 2012: Critical Care -management

The evaluation of sivelestat sodium hydrate in acute lung injury/acute respiratory distress syndrome patients in the intensive care unit

Risk factors for the development of acute lung injury in patients with septic shock: an observational cohort study

Surfactant therapy for acute respiratory failure in children: a systematic review and meta-analysis

Is extravascular lung water index useful for the diagnostic accuracy of lung injury in patients with shock? We need more evidence

Pressure dependency of respiratory resistance in patients with acute lung injury and acute respiratory distress syndrome

A prospective pilot study of the effect of neutrophil elastase on the pulmonary vascular permeability in patients with pneumonia

Airway pressure release ventilation (APRV) enhances cardiac performance in patients with acute lung injury (ALI)/adult respiratory distress syndrome (ARDS)

Risk factors for the development of acute lung injury in patients with infectious pneumonia

Similar Documents

Risk factors for the development of acute lung injury in patients with infectious pneumonia

Year in review 2012: Critical Care -management

The evaluation of sivelestat sodium hydrate in acute lung injury/acute respiratory distress syndrome patients in the intensive care unit

Risk factors for the development of acute lung injury in patients with septic shock: an observational cohort study

Surfactant therapy for acute respiratory failure in children: a systematic review and meta-analysis

Is extravascular lung water index useful for the diagnostic accuracy of lung injury in patients with shock? We need more evidence

Pressure dependency of respiratory resistance in patients with acute lung injury and acute respiratory distress syndrome

A prospective pilot study of the effect of neutrophil elastase on the pulmonary vascular permeability in patients with pneumonia

Airway pressure release ventilation (APRV) enhances cardiac performance in patients with acute lung injury (ALI)/adult respiratory distress syndrome (ARDS)

Risk factors for the development of acute lung injury in patients with infectious pneumonia