NDLI: Atrial natriuretic peptide infusion and nitric oxide inhalation in patients with acute respiratory distress syndrome

Content Provider	Springer Nature : BioMed Central
Author	Bindels, Alexander JGH van der Hoeven, Johannes G Groeneveld, Paul HP Frölich, Marijke Meinders, Arend E
Abstract	Aim To study the effects of infusion of atrial natriuretic peptide (ANP) versus the inhalation of nitric oxide (NO) in patients with an early acute respiratory distress syndrome (ARDS). Methods Ten patients with severe ARDS were studied in a crossover study design, within 72 hours after starting mechanical ventilation. We studied the effects of ANP infusion (10 ng/kg/min for 1 hour) and of inhalation of NO (20 ppm for 1 hour) on hemodynamic and respiratory patient parameters, as well as the effects on plasma levels of ANP, guanosine 3',5'-cyclic monophosphate, nitrate and endothelin-1. Results Despite an approximate 50% increase in mixed venous ANP plasma concentration (from 86 ± 21 to 123 ± 33 ng/l, P < 0.05) during ANP infusion, there were no changes in mean pulmonary artery pressure, pulmonary vascular resistance index, extravascular lung water index, or in pulmonary gas exchange. NO inhalation, in contrast, lowered mean pulmonary artery pressure (from 26 ± 1.9 to 23.9 ± 1.7 mmHg, P < 0.01), pulmonary vascular resistance index (from 314 ± 37 to 273 ± 32 dynes/cm5/m2, P < 0.05) and central venous pressure (from 8.2 ± 1.2 to 7.3 ± 1.1 mmHg, P < 0.02). Furthermore, NO inhalation improved pulmonary gas exchange, reflected by a decrease in alveolar-arterial oxygen gradient (from 41.9 ± 3.9 to 40.4 ± 3.6 kPa, P < 0.05), a small increase in oxygenation (PaO2/FiO2 from 17.7 ± 1.4 to 19.7 ± 1.1 kPa, P = 0.07) and a small decrease in venous admixture (Qs/Qt from 35.7 ± 2.0 to 32.8 ± 2.7%, P = 0.11). Conclusion This study shows that, in contrast to NO inhalation, infusion of ANP neither improves oxygenation nor attenuates pulmonary hypertension or pulmonary edema in patients with severe ARDS.
Related Links	https://ccforum.biomedcentral.com/counter/pdf/10.1186/cc1015.pdf
Ending Page	7
Page Count	7
Starting Page	1
File Format	HTM / HTML
ISSN	13648535
DOI	10.1186/cc1015
Journal	Critical Care
Issue Number	3
Volume Number	5
Language	English
Publisher	BioMed Central
Publisher Date	2001-04-20
Access Restriction	Open
Subject Keyword	Intensive Critical Care Medicine Emergency Medicine acute respiratory distress syndrome atrial natriuretic peptide extravascular lung water nitric oxide
Content Type	Text
Resource Type	Article
Subject	Critical Care and Intensive Care Medicine
Journal Impact Factor	8.8/2023
5-Year Journal Impact Factor	10.4/2023

Sl.	Authority	Responsibilities	Communication Details
1	Ministry of Education (GoI), Department of Higher Education	Sanctioning Authority	https://www.education.gov.in/ict-initiatives
2	Indian Institute of Technology Kharagpur	Host Institute of the Project: The host institute of the project is responsible for providing infrastructure support and hosting the project	https://www.iitkgp.ac.in
3	National Digital Library of India Office, Indian Institute of Technology Kharagpur	The administrative and infrastructural headquarters of the project	Dr. B. Sutradhar bsutra@ndl.gov.in
4	Project PI / Joint PI	Principal Investigator and Joint Principal Investigators of the project	Dr. B. Sutradhar bsutra@ndl.gov.in Prof. Saswat Chakrabarti will be added soon
5	Website/Portal (Helpdesk)	Queries regarding NDLI and its services	support@ndl.gov.in
6	Contents and Copyright Issues	Queries related to content curation and copyright issues	content@ndl.gov.in
7	National Digital Library of India Club (NDLI Club)	Queries related to NDLI Club formation, support, user awareness program, seminar/symposium, collaboration, social media, promotion, and outreach	clubsupport@ndl.gov.in
8	Digital Preservation Centre (DPC)	Assistance with digitizing and archiving copyright-free printed books	dpc@ndl.gov.in
9	IDR Setup or Support	Queries related to establishment and support of Institutional Digital Repository (IDR) and IDR workshops	idr@ndl.gov.in

Atrial natriuretic peptide infusion and nitric oxide inhalation in patients with acute respiratory distress syndrome

Atrial natriuretic peptide infusion and nitric oxide inhalation in patients with acute respiratory distress syndrome

Extravascular lung water in patients with severe sepsis: a prospective cohort study

Extravascular lung water in acute respiratory distress syndrome: potential clinical value, assumptions and limitations

Extravascular lung water and pulmonary vascular permeability index may inadvertently delay the identification of acute respiratory distress syndrome

Extravascular lung water index improves the diagnostic accuracy of lung injury in patients with shock

Accurate characterization of extravascular lung water in acute respiratory distress syndrome*

Effect of continuous high-volume hemofiltration on patients with acute respiratory distress syndrome

Atrial and brain natriuretic peptide concentrations and the response to inhaled nitric oxide in patients with acute respiratory distress syndrome.

Atrial natriuretic peptide infusion and nitric oxide inhalation in patients with acute respiratory distress syndrome

Similar Documents

Atrial natriuretic peptide infusion and nitric oxide inhalation in patients with acute respiratory distress syndrome

Atrial natriuretic peptide infusion and nitric oxide inhalation in patients with acute respiratory distress syndrome

Extravascular lung water in patients with severe sepsis: a prospective cohort study

Extravascular lung water in acute respiratory distress syndrome: potential clinical value, assumptions and limitations

Extravascular lung water and pulmonary vascular permeability index may inadvertently delay the identification of acute respiratory distress syndrome

Extravascular lung water index improves the diagnostic accuracy of lung injury in patients with shock

Accurate characterization of extravascular lung water in acute respiratory distress syndrome*

Effect of continuous high-volume hemofiltration on patients with acute respiratory distress syndrome

Atrial and brain natriuretic peptide concentrations and the response to inhaled nitric oxide in patients with acute respiratory distress syndrome.

Atrial natriuretic peptide infusion and nitric oxide inhalation in patients with acute respiratory distress syndrome