NDLI: Total cholesterol and triglycerides are associated with the development of new bone marrow lesions in asymptomatic middle-aged women

Content Provider	Springer Nature : BioMed Central
Author	Davies-Tuck, Miranda L Hanna, Fahad Davis, Susan R Bell, Robin J Davison, Sonia L Wluka, Anita E Adams, Jenny Cicuttini, Flavia M
Abstract	Introduction Given the emerging evidence that osteoarthritis (OA) may have a vascular basis, the aim of this study was to determine whether serum lipids were associated with change in knee cartilage, presence of bone marrow lesions (BMLs) at baseline and the development of new BMLs over a 2-year period in a population of pain-free women in mid-life. Methods One hundred forty-eight women 40 to 67 years old underwent magnetic resonance imaging (MRI) of their dominant knee at baseline and 2.2 (standard deviation 0.12) years later. Cartilage volume and BMLs were determined for both time points. Serum lipids were measured from a single-morning fasting blood test approximately 1.5 years prior to the MRI. Results The incidence of BML at follow-up was associated with higher levels of total cholesterol (odds ratio [OR] 1.84, 95% confidence interval [CI] 1.01, 3.36; P = 0.048) and triglycerides (OR 8.4, 95% CI 1.63, 43.43; P = 0.01), but not high-density lipoprotein (HDL) (P = 0.93), low-density lipoprotein (LDL) (P = 0.20) or total cholesterol/HDL ratio (P = 0.17). No association between total cholesterol, triglycerides, HDL, LDL or total cholesterol/HDL ratio and presence of BMLs at baseline or annual change in total tibial cartilage volume was observed. Conclusions In this study of asymptomatic middle-aged women with no clinical knee OA, serum cholesterol and triglyceride levels were associated with the incidence of BMLs over 2 years. This provides support for the hypothesis that vascular pathology may have a role in the pathogenesis of knee OA. Further work is warranted to clarify this and whether treatments aimed at reducing serum lipids may have a role in reducing the burden of knee OA.
Related Links	https://arthritis-research.biomedcentral.com/counter/pdf/10.1186/ar2873.pdf
Ending Page	7
Page Count	7
Starting Page	1
File Format	HTM / HTML
ISSN	14786362
DOI	10.1186/ar2873
Journal	Arthritis Research & Therapy
Issue Number	6
Volume Number	11
Language	English
Publisher	BioMed Central
Publisher Date	2009-12-04
Access Restriction	Open
Subject Keyword	Rheumatology Orthopedics Serum Lipid Cartilage Volume Bone Marrow Lesion Knee Cartilage Knee Magnetic Resonance Imaging
Content Type	Text
Resource Type	Article
Subject	Immunology and Allergy Immunology Rheumatology
Journal Impact Factor	4.4/2023
5-Year Journal Impact Factor	4.9/2023

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