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Acidosis induces reprogramming of cellular metabolism to mitigate oxidative stress

PGC-1α supports glutamine metabolism in breast cancer

Deficiency of metabolic regulator FGFR4 delays breast cancer progression through systemic and microenvironmental metabolic alterations

The metabolic demands of cancer cells are coupled to their size and protein synthesis rates

Quinoline 3-sulfonamides inhibit lactate dehydrogenase A and reverse aerobic glycolysis in cancer cells

LKB1 is a central regulator of tumor initiation and pro-growth metabolism in ErbB2-mediated breast cancer

Ets-1 global gene expression profile reveals associations with metabolism and oxidative stress in ovarian and breast cancers

Linking vitamin B1 with cancer cell metabolism

Cerebellar granule neuron progenitors are the source of Hk2 in the postnatal cerebellum

The role of Bergmann glial cells in cerebellar development

Expression and phosphorylation of the AS160_v2 splice variant supports GLUT4 activation and the Warburg effect in multiple myeloma

Reversed argininosuccinate lyase activity in fumarate hydratase-deficient cancer cells

Respiratory complex I is essential to induce a Warburg profile in mitochondria-defective tumor cells

Calorie restriction and cancer prevention: a mechanistic perspective

Balancing glycolytic flux: the role of 6-phosphofructo-2-kinase/fructose 2,6-bisphosphatases in cancer metabolism

Metabolic changes in cancer cells upon suppression of MYC

p53 promotes the expression of gluconeogenesis-related genes and enhances hepatic glucose production

Activated lymphocytes as a metabolic model for carcinogenesis

Hexokinase-2-mediated aerobic glycolysis is integral to cerebellar neurogenesis and pathogenesis of medulloblastoma

Monitoring metabolic responses to chemotherapy in single cells and tumors using nanostructure-initiator mass spectrometry (NIMS) imaging

Sterol regulatory element binding protein-dependent regulation of lipid synthesis supports cell survival and tumor growth

The long and winding road to the mitochondrial pyruvate carrier

Why Cancer & Metabolism? Why now?

Balancing glycolytic flux: the role of 6-phosphofructo-2-kinase/fructose 2,6-bisphosphatases in cancer metabolism

Content Provider	Springer Nature : BioMed Central
Author	Ros, Susana Schulze, Almut
Abstract	The increased glucose metabolism in cancer cells is required to fulfill their high energetic and biosynthetic demands. Changes in the metabolic activity of cancer cells are caused by the activation of oncogenes or loss of tumor suppressors. They can also be part of the metabolic adaptations to the conditions imposed by the tumor microenvironment, such as the hypoxia response. Among the metabolic enzymes that are modulated by these factors are the 6-phosphofructo-2-kinase/fructose 2,6-bisphosphatases (PFKFBs), a family of bifunctional enzymes that control the levels of fructose 2,6-bisphosphate (Fru-2,6-P2). This metabolite is important for the dynamic regulation of glycolytic flux by allosterically activating the rate-limiting enzyme of glycolysis phosphofructokinase-1 (PFK-1). Therapeutic strategies designed to alter the levels of this metabolite are likely to interfere with the metabolic balance of cancer cells, and could lead to a reduction in cancer cell proliferation, invasiveness and survival. This article will review our current understanding of the role of PFKFB proteins in the control of cancer metabolism and discuss the emerging interest in these enzymes as potential targets for the development of antineoplastic agents.
Related Links	https://cancerandmetabolism.biomedcentral.com/counter/pdf/10.1186/2049-3002-1-8.pdf
Ending Page	10
Page Count	10
Starting Page	1
File Format	HTM / HTML
ISSN	20493002
DOI	10.1186/2049-3002-1-8
Journal	Cancer & Metabolism
Issue Number	1
Volume Number	1
Language	English
Publisher	BioMed Central
Publisher Date	2013-02-04
Access Restriction	Open
Subject Keyword	Cancer Research Oncology Metabolomics Metabolic Diseases Imaging Radiology Cell Biology Cancer metabolism Fructose 2,6-bisphosphate PFK-2/FBPase-2
Content Type	Text
Resource Type	Review
Subject	Cancer Research
Journal Impact Factor	6/2023
5-Year Journal Impact Factor	5.4/2023

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Balancing glycolytic flux: the role of 6-phosphofructo-2-kinase/fructose 2,6-bisphosphatases in cancer metabolism

Interaction of 6-Phosphofructo-2-Kinase/Fructose-2,6-Bisphosphatase (PFK-2/FBPase-2) With Glucokinase Activates Glucose Phosphorylation and Glucose Metabolism in Insulin-Producing Cells

Expression of Inducible 6-Phosphofructo-2-Kinase/Fructose-2,6-Bisphosphatase/PFKFB3 Isoforms in Adipocytes and Their Potential Role in Glycolytic Regulation

TIGAR, TIGAR, burning bright

Contractile Activity Modifies Fru-2,6-P2 Metabolism in Rabbit Fast Twitch Skeletal Muscle

Fructose-2,6-bisphosphate links glucose to survival and growth

Fructose-2,6-Bisphosphate synthesis by 6-Phosphofructo-2-Kinase/Fructose-2,6-Bisphosphatase 4 (PFKFB4) is required for the glycolytic response to hypoxia and tumor growth

Regulation of Energy Metabolism in Macrophages during Hypoxia ROLES OF FRUCTOSE 2,6-BISPHOSPHATE AND RIBOSE 1,5-BISPHOSPHATE

Tissue-specific Structure/Function Differentiation of the Liver Isoform of 6-Phosphofructo-2-kinase/Fructose-2,6-bisphosphatase

Balancing glycolytic flux: the role of 6-phosphofructo-2-kinase/fructose 2,6-bisphosphatases in cancer metabolism

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