| Content Provider | Springer Nature : BioMed Central |
|---|---|
| Author | Hausner, Georg Hafez, Mohamed Edgell, David R |
| Abstract | Group I introns are intervening sequences that have invaded tRNA, rRNA and protein coding genes in bacteria and their phages. The ability of group I introns to self-splice from their host transcripts, by acting as ribozymes, potentially renders their insertion into genes phenotypically neutral. Some group I introns are mobile genetic elements due to encoded homing endonuclease genes that function in DNA-based mobility pathways to promote spread to intronless alleles. Group I introns have a limited distribution among bacteria and the current assumption is that they are benign selfish elements, although some introns and homing endonucleases are a source of genetic novelty as they have been co-opted by host genomes to provide regulatory functions. Questions regarding the origin and maintenance of group I introns among the bacteria and phages are also addressed. |
| Related Links | https://mobilednajournal.biomedcentral.com/counter/pdf/10.1186/1759-8753-5-8.pdf |
| Ending Page | 12 |
| Page Count | 12 |
| Starting Page | 1 |
| File Format | HTM / HTML |
| ISSN | 17598753 |
| DOI | 10.1186/1759-8753-5-8 |
| Journal | Mobile DNA |
| Issue Number | 1 |
| Volume Number | 5 |
| Language | English |
| Publisher | BioMed Central |
| Publisher Date | 2014-03-10 |
| Access Restriction | Open |
| Subject Keyword | Human Genetics Animal Genetics and Genomics Plant Genetics and Genomics Developmental Biology Microbiology Microbial Genetics and Genomics Evolution Group I introns Intron splicing Intron mobility Homing endonuclease genes IStrons |
| Content Type | Text |
| Resource Type | Review |
| Subject | Molecular Biology |
| Journal Impact Factor | 4.7/2023 |
| 5-Year Journal Impact Factor | 4.3/2023 |
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