NDLI: The Nordic long-term OCD treatment study (NordLOTS): rationale, design, and methods

Content Provider	Springer Nature : BioMed Central
Author	Thomsen, Per Hove Torp, Nor C Dahl, Kitty Christensen, Karin Englyst, Inger Melin, Karin H Nissen, Judith B Hybel, Katja A Valderhaug, Robert Weidle, Bernhard Skarphedinsson, Gudmundur von Bahr, Petra Lindheim Ivarsson, Tord
Abstract	Background This paper describes and discusses the methodology of the Nordic long-term OCD-treatment study (NordLOTS). The purpose of this effectiveness study was to study treatment outcome of CBT, to identify CBT non- or partial responders and to investigate whether an increased number of CBT-sessions or sertraline treatment gives the best outcome; to identify treatment refractory patients and to investigate the outcome of aripiprazole augmentation; to study the outcome over a three year period for each responder including the risk of relapse, and finally to study predictors, moderators and mediators of treatment response. Methods Step 1 was an open and uncontrolled clinical trial with CBT, step 2 was a controlled, randomised non-blinded study of CBT non-responders from step 1. Patients were randomized to receive either sertraline plus CBT-support or continued and modified CBT. In step 3 patients who did not respond to either CBT or sertraline were treated with aripiprazole augmentation to sertraline. Conclusions This multicenter trial covering three Scandinavian countries is going to be the largest CBT-study for paediatric OCD to date. It is not funded by industry and tries in the short and long-term to answer the question whether further CBT or SSRI is better in CBT non-responders.
Related Links	https://capmh.biomedcentral.com/counter/pdf/10.1186/1753-2000-7-41.pdf
Ending Page	13
Page Count	13
Starting Page	1
File Format	HTM / HTML
ISSN	17532000
DOI	10.1186/1753-2000-7-41
Journal	Child and Adolescent Psychiatry and Mental Health
Issue Number	1
Volume Number	7
Language	English
Publisher	BioMed Central
Publisher Date	2013-12-19
Access Restriction	Open
Subject Keyword	Psychiatry Pediatrics Clinical Psychology Child and Adolescent Psychiatry Forensic Psychiatry Study design Multisite study Child and adolescents Obsessive-compulsive disorder Cognitive behavioural therapy Stepped care design Treatment outcome
Content Type	Text
Resource Type	Article
Subject	Pediatrics, Perinatology and Child Health Psychiatry and Mental Health
Journal Impact Factor	3.4/2023
5-Year Journal Impact Factor	4.4/2023

Sl.	Authority	Responsibilities	Communication Details
1	Ministry of Education (GoI), Department of Higher Education	Sanctioning Authority	https://www.education.gov.in/ict-initiatives
2	Indian Institute of Technology Kharagpur	Host Institute of the Project: The host institute of the project is responsible for providing infrastructure support and hosting the project	https://www.iitkgp.ac.in
3	National Digital Library of India Office, Indian Institute of Technology Kharagpur	The administrative and infrastructural headquarters of the project	Dr. B. Sutradhar bsutra@ndl.gov.in
4	Project PI / Joint PI	Principal Investigator and Joint Principal Investigators of the project	Dr. B. Sutradhar bsutra@ndl.gov.in Prof. Saswat Chakrabarti will be added soon
5	Website/Portal (Helpdesk)	Queries regarding NDLI and its services	support@ndl.gov.in
6	Contents and Copyright Issues	Queries related to content curation and copyright issues	content@ndl.gov.in
7	National Digital Library of India Club (NDLI Club)	Queries related to NDLI Club formation, support, user awareness program, seminar/symposium, collaboration, social media, promotion, and outreach	clubsupport@ndl.gov.in
8	Digital Preservation Centre (DPC)	Assistance with digitizing and archiving copyright-free printed books	dpc@ndl.gov.in
9	IDR Setup or Support	Queries related to establishment and support of Institutional Digital Repository (IDR) and IDR workshops	idr@ndl.gov.in

The Pediatric Obsessive-Compulsive Disorder Treatment Study II: rationale, design and methods

The Nordic long-term OCD treatment study (NordLOTS): rationale, design, and methods

Acceptability and feasibility of enhanced cognitive behavioral therapy (eCBT) for children and adolescents with obsessive–compulsive disorder

Psychometric evaluation of a parent-rating and self-rating inventory for pediatric obsessive-compulsive disorder: German OCD Inventory for Children and Adolescents (OCD-CA)

Extended treatment of multimodal cognitive behavioral therapy in children and adolescents with obsessive–compulsive disorder improves symptom reduction: a within-subject design

Lived experiences of children and adolescents with obsessive–compulsive disorder: interpretative phenomenological analysis

Cognitive behavioral therapy for pediatric obsessive-compulsive disorder delivered via internet videoconferencing: a manualized sensor-assisted feasibility approach

Multiple forms of discrimination and obsessive-compulsive disorder: a prospective cohort study

eCBT Versus Standard Individual CBT for Paediatric Obsessive-Compulsive Disorder.

The Nordic long-term OCD treatment study (NordLOTS): rationale, design, and methods

Similar Documents

The Pediatric Obsessive-Compulsive Disorder Treatment Study II: rationale, design and methods

The Nordic long-term OCD treatment study (NordLOTS): rationale, design, and methods

Acceptability and feasibility of enhanced cognitive behavioral therapy (eCBT) for children and adolescents with obsessive–compulsive disorder

Psychometric evaluation of a parent-rating and self-rating inventory for pediatric obsessive-compulsive disorder: German OCD Inventory for Children and Adolescents (OCD-CA)

Extended treatment of multimodal cognitive behavioral therapy in children and adolescents with obsessive–compulsive disorder improves symptom reduction: a within-subject design

Lived experiences of children and adolescents with obsessive–compulsive disorder: interpretative phenomenological analysis

Cognitive behavioral therapy for pediatric obsessive-compulsive disorder delivered via internet videoconferencing: a manualized sensor-assisted feasibility approach

Multiple forms of discrimination and obsessive-compulsive disorder: a prospective cohort study

eCBT Versus Standard Individual CBT for Paediatric Obsessive-Compulsive Disorder.

The Nordic long-term OCD treatment study (NordLOTS): rationale, design, and methods