| Content Provider | Springer Nature : BioMed Central |
|---|---|
| Author | Zheng, Hui Koo, Edward H |
| Abstract | The amyloid precursor protein (APP) takes a central position in Alzheimer's disease (AD) pathogenesis: APP processing generates the β-amyloid (Aβ) peptides, which are deposited as the amyloid plaques in brains of AD individuals; Point mutations and duplications of APP are causal for a subset of early onset of familial Alzheimer's disease (FAD). Not surprisingly, the production and pathogenic effect of Aβ has been the central focus in AD field. Nevertheless, the biological properties of APP have also been the subject of intense investigation since its identification nearly 20 years ago as it demonstrates a number of interesting putative physiological roles. Several attractive models of APP function have been put forward recently based on in vitro biochemical studies. Genetic analyses of gain- and loss-of-function mutants in Drosophila and mouse have also revealed important insights into its biological activities in vivo. This article will review the current understanding of APP physiological functions. |
| Related Links | https://molecularneurodegeneration.biomedcentral.com/counter/pdf/10.1186/1750-1326-1-5.pdf |
| Ending Page | 12 |
| Page Count | 12 |
| Starting Page | 1 |
| File Format | HTM / HTML |
| ISSN | 17501326 |
| DOI | 10.1186/1750-1326-1-5 |
| Journal | Molecular Neurodegeneration |
| Issue Number | 1 |
| Volume Number | 1 |
| Language | English |
| Publisher | BioMed Central |
| Publisher Date | 2006-07-03 |
| Access Restriction | Open |
| Subject Keyword | Neurosciences Neurology Molecular Medicine Amyloid Precursor Protein Amyloid Precursor Protein Gene Thr668 Phosphorylation Amyloid Precursor Protein Transgenic Mouse Kinesin Light Chain |
| Content Type | Text |
| Resource Type | Review |
| Subject | Neurology (clinical) Molecular Biology Cellular and Molecular Neuroscience |
| Journal Impact Factor | 15.1/2023 |
| 5-Year Journal Impact Factor | 16.8/2023 |
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