NDLI: High-dose proton beam therapy for sinonasal mucosal malignant melanoma

Content Provider	Springer Nature : BioMed Central
Author	Fuji, Hiroshi Yoshikawa, Shusuke Kasami, Masako Murayama, Shigeyuki Onitsuka, Tetsuro Kashiwagi, Hiroya Kiyohara, Yoshio
Abstract	Background The significance of definitive radiotherapy for sinonasal mucosal melanoma (SMM) is sill controvertial. T his study was to evaluate the role of high-dose proton beam therapy (PBT) in patients with SMM. Methods The cases of 20 patients with SMM localized to the primary site who were treated by PBT between 2006 and 2012 were retrospectively analyzed. The patterns of overall survival and morbidity were assessed. Results The median follow-up time was 35 months (range, 6–77 months). The 5-year overall and disease-free survival rates were 51% and 38%, respectively. Four patients showed local failure, 2 showed regrowth of the primary tumor, and 2 showed new sinonasal tumors beyond the primary site. The 5-year local control rate after PBT was 62%. Nodal and distant failure was seen in 7 patients. Three grade 4 late toxicities were observed in tumor-involved optic nerve. Conclusion Our findings suggested that high-dose PBT is an effective local treatment that is less invasive than surgery but with comparable outcomes.
Related Links	https://ro-journal.biomedcentral.com/counter/pdf/10.1186/1748-717X-9-162.pdf
Ending Page	7
Page Count	7
Starting Page	1
File Format	HTM / HTML
DOI	10.1186/1748-717X-9-162
Journal	Radiation Oncology
Issue Number	1
Volume Number	9
Language	English
Publisher	BioMed Central
Publisher Date	2014-07-23
Access Restriction	Open
Subject Keyword	Cancer Research Oncology Radiotherapy Imaging Radiology Mucosal melanoma Proton beam therapy Sinonasal melanoma
Content Type	Text
Resource Type	Article
Subject	Radiology, Nuclear Medicine and Imaging Oncology
Journal Impact Factor	3.3/2023
5-Year Journal Impact Factor	3.6/2023

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