NDLI: Safety and feasibility of oral immunotherapy to multiple allergens for food allergy

Content Provider	Springer Nature : BioMed Central
Author	Bégin, Philippe Winterroth, Lisa C Dominguez, Tina Wilson, Shruti P Bacal, Liane Mehrotra, Anjuli Kausch, Bethany Trela, Anthony Hoyte, Elisabeth O’Riordan, Gerri Seki, Scott Blakemore, Alanna Woch, Margie Hamilton, Robert G Nadeau, Kari C
Abstract	Background Thirty percent of children with food allergy are allergic to more than one food. Previous studies on oral immunotherapy (OIT) for food allergy have focused on the administration of a single allergen at the time. This study aimed at evaluating the safety of a modified OIT protocol using multiple foods at one time. Methods Participants underwent double-blind placebo-controlled food challenges (DBPCFC) up to a cumulative dose of 182 mg of food protein to peanut followed by other nuts, sesame, dairy or egg. Those meeting inclusion criteria for peanut only were started on single-allergen OIT while those with additional allergies had up to 5 foods included in their OIT mix. Reactions during dose escalations and home dosing were recorded in a symptom diary. Results Forty participants met inclusion criteria on peanut DBPCFC. Of these, 15 were mono-allergic to peanut and 25 had additional food allergies. Rates of reaction per dose did not differ significantly between the two groups (median of 3.3% and 3.7% in multi and single OIT group, respectively; p = .31). In both groups, most reactions were mild but two severe reactions requiring epinephrine occurred in each group. Dose escalations progressed similarly in both groups although, per protocol design, those on multiple food took longer to reach equivalent doses per food (median +4 mo.; p < .0001). Conclusions Preliminary data show oral immunotherapy using multiple food allergens simultaneously to be feasible and relatively safe when performed in a hospital setting with trained personnel. Additional, larger, randomized studies are required to continue to test safety and efficacy of multi-OIT. Trial registration Clinicaltrial.gov NCT01490177
Related Links	https://aacijournal.biomedcentral.com/counter/pdf/10.1186/1710-1492-10-1.pdf
Ending Page	8
Page Count	8
Starting Page	1
File Format	HTM / HTML
ISSN	17101492
DOI	10.1186/1710-1492-10-1
Journal	Allergy, Asthma & Clinical Immunology
Issue Number	1
Volume Number	10
Language	English
Publisher	BioMed Central
Publisher Date	2014-01-15
Access Restriction	Open
Subject Keyword	Allergy Asthma & Clinical Immunology Allergology Immunology Pneumology Respiratory System Food allergy Oral immunotherapy (OIT) Specific oral tolerance induction (SOTI) Multiple Safety Efficacy Pneumology/Respiratory System
Content Type	Text
Resource Type	Article
Subject	Immunology and Allergy Pulmonary and Respiratory Medicine Immunology
Journal Impact Factor	2.6/2023
5-Year Journal Impact Factor	3.5/2023

Sl.	Authority	Responsibilities	Communication Details
1	Ministry of Education (GoI), Department of Higher Education	Sanctioning Authority	https://www.education.gov.in/ict-initiatives
2	Indian Institute of Technology Kharagpur	Host Institute of the Project: The host institute of the project is responsible for providing infrastructure support and hosting the project	https://www.iitkgp.ac.in
3	National Digital Library of India Office, Indian Institute of Technology Kharagpur	The administrative and infrastructural headquarters of the project	Dr. B. Sutradhar bsutra@ndl.gov.in
4	Project PI / Joint PI	Principal Investigator and Joint Principal Investigators of the project	Dr. B. Sutradhar bsutra@ndl.gov.in Prof. Saswat Chakrabarti will be added soon
5	Website/Portal (Helpdesk)	Queries regarding NDLI and its services	support@ndl.gov.in
6	Contents and Copyright Issues	Queries related to content curation and copyright issues	content@ndl.gov.in
7	National Digital Library of India Club (NDLI Club)	Queries related to NDLI Club formation, support, user awareness program, seminar/symposium, collaboration, social media, promotion, and outreach	clubsupport@ndl.gov.in
8	Digital Preservation Centre (DPC)	Assistance with digitizing and archiving copyright-free printed books	dpc@ndl.gov.in
9	IDR Setup or Support	Queries related to establishment and support of Institutional Digital Repository (IDR) and IDR workshops	idr@ndl.gov.in

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