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| Content Provider | Springer Nature : BioMed Central |
|---|---|
| Author | Lv, Chao Ma, Yuanyuan Wu, Nan Yan, Shi Zheng, Qingfeng Sun, Yu Li, Shaolei Fang, Jian Yang, Yue |
| Abstract | Background Several encouraging phase III clinical trials have evaluated platinum-based induction chemotherapy against stage IIB-IIIA non-small-cell lung cancer (NSCLC). Chemotherapy efficacy was assessed using common regimens in this retrospective analysis. Methods From 2007 to 2011, the clinical records of stage IIB-IIIA NSCLC patients undergoing surgery after neoadjuvant chemotherapy were reviewed. Gathered data were tested for significance and variables impacting survival were assessed by univariate and Cox regression analyses. Results Overall, 84% of patients were male and 93% had central disease. Platinum-based chemotherapy protocols with gemcitabine or paclitaxel gave an overall response rate of 55% (45/82) and 6.1% pathological complete response (5/82). Clinical response was unassociated with regimen or histology, while more pneumonectomies were performed in the stable compared to partial response disease group (P =0.040). Postoperative mortality was 1.2% (1/82), and complications, unassociated with regimen or histology, were atelectasis (26.8%) and supraventricular arrhythmias (13.4%). Right-sided procedures appeared to increase the incidence of bronchopleural fistula (P =0.073). The median disease-free survival time was 18 months and median overall survival time was not reached. Disease-free survival rates at one, two, and three years were 54%, 47%, and 33%, while the overall survival rate was 73%, 69%, and 59%, respectively. Disease-free survival predictors were radiographic response and mediastinal lymphadenopathy before chemotherapy (P =0.012 and 0.002, respectively). Conclusions Two cycles of platinum-based chemotherapy with gemcitabine or paclitaxel is efficacious for patients with stage IIB-IIIA central disease. Patients achieving clinical response had improved disease-free survival times, while those with mediastinal lymphadenopathy had a higher postoperative recurrence risk. |
| Related Links | https://wjso.biomedcentral.com/counter/pdf/10.1186/1477-7819-11-76.pdf |
| Ending Page | 11 |
| Page Count | 11 |
| Starting Page | 1 |
| File Format | HTM / HTML |
| ISSN | 14777819 |
| DOI | 10.1186/1477-7819-11-76 |
| Journal | World Journal of Surgical Oncology |
| Issue Number | 1 |
| Volume Number | 11 |
| Language | English |
| Publisher | BioMed Central |
| Publisher Date | 2013-03-21 |
| Access Restriction | Open |
| Subject Keyword | Surgical Oncology Non-small-cell lung cancer Induction chemotherapy Central disease Resection Squamous |
| Content Type | Text |
| Resource Type | Article |
| Subject | Oncology Surgery |
| Journal Impact Factor | 2.5/2023 |
| 5-Year Journal Impact Factor | 2.8/2023 |
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