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| Content Provider | Springer Nature : BioMed Central |
|---|---|
| Author | Sirinak, Chawin Kittikraisak, Wanitchaya Pinjeesekikul, Duangporn Charusuntonsri, Pricha Luanloed, Phinai Srisuwanvilai, La-ong Nateniyom, Sriprapa Akksilp, Somsak Likanonsakul, Sirirat Sattayawuthipong, Wanchai Burapat, Channawong Varma, Jay K |
| Abstract | Background The occurrence of tuberculosis (TB), human immunodeficiency virus (HIV), and viral hepatitis infections in the same patient poses unique clinical and public health challenges, because medications to treat TB and HIV are hepatotoxic. We conducted an observational study to evaluate risk factors for HBsAg and/or anti-HCV reactivity and to assess differences in adverse events and TB treatment outcomes among HIV-infected TB patients. Methods Patients were evaluated at the beginning, during, and at the end of TB treatment. Blood samples were tested for aspartate aminotransferase (AST), alanine aminotransferase (ALT), total bilirubin (BR), complete blood count, and CD4+ T lymphocyte cell count. TB treatment outcomes were assessed at the end of TB treatment according to international guidelines. Results Of 769 enrolled patients, 752 (98%) had serologic testing performed for viral hepatitis: 70 (9%) were reactive for HBsAg, 237 (31%) for anti-HCV, and 472 (63%) non-reactive for both markers. At the beginning of TB treatment, 18 (26%) patients with HBsAg reactivity had elevated liver function tests compared with 69 (15%) patients non-reactive to any viral marker (p = 0.02). At the end of TB treatment, 493 (64%) were successfully treated. Factors independently associated with HBsAg reactivity included being a man who had sex with men (adjusted odds ratio [AOR], 2.1; 95% confidence interval [CI], 1.1–4.3) and having low TB knowledge (AOR, 1.8; CI, 1.0–3.0). Factors most strongly associated with anti-HCV reactivity were having injection drug use history (AOR, 12.8; CI, 7.0–23.2) and living in Bangkok (AOR, 15.8; CI, 9.4–26.5). The rate of clinical hepatitis and death during TB treatment was similar in patients HBsAg reactive, anti-HCV reactive, both HBsAg and anti-HCV reactive, and non-reactive to any viral marker. Conclusion Among HIV-infected TB patients living in Thailand, markers of viral hepatitis infection, particularly hepatitis C virus infection, were common and strongly associated with known behavioral risk factors. Viral hepatitis infection markers were not strongly associated with death or the development of clinical hepatitis during TB treatment. |
| Related Links | https://bmcpublichealth.biomedcentral.com/counter/pdf/10.1186/1471-2458-8-245.pdf |
| Ending Page | 10 |
| Page Count | 10 |
| Starting Page | 1 |
| File Format | HTM / HTML |
| ISSN | 14712458 |
| DOI | 10.1186/1471-2458-8-245 |
| Journal | BMC Public Health |
| Issue Number | 1 |
| Volume Number | 8 |
| Language | English |
| Publisher | BioMed Central |
| Publisher Date | 2008-07-18 |
| Access Restriction | Open |
| Subject Keyword | Public Health Medicine Epidemiology Biostatistics Vaccine Environmental Health Human Immunodeficiency Virus Human Immunodeficiency Virus Infection Viral Hepatitis Infection Clinical Hepatitis Viral Hepatitis Marker Medicine/Public Health |
| Content Type | Text |
| Resource Type | Article |
| Subject | Public Health, Environmental and Occupational Health |
| Journal Impact Factor | 3.5/2023 |
| 5-Year Journal Impact Factor | 3.9/2023 |
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