NDLI: Hippocampal activity during the transverse patterning task declines with cognitive competence but not with age

Content Provider	Springer Nature : BioMed Central
Author	Leirer, Vera M Wienbruch, Christian Paul-Jordanov, Isabella Kolassa, Stephan Elbert, Thomas Kolassa, Iris T
Abstract	The hippocampus is a brain region that is particularly affected by age-related morphological changes. It is generally assumed that a loss in hippocampal volume results in functional deficits that contribute to age-related cognitive decline. In a combined cross-sectional behavioural and magnetoencephalography (MEG) study we investigated whether hippocampal-associated neural current flow during a transverse patterning task - which requires learning relational associations between stimuli - correlates with age and whether it is modulated by cognitive competence. Better performance in several tests of verbal memory, verbal fluency and executive function was indeed associated with higher hippocampal neural activity. Age, however, was not related to the strength of hippocampal neural activity: elderly participants responded slower than younger individuals but on average produced the same neural mass activity. Our results suggest that in non-pathological aging, hippocampal neural activity does not decrease with age but is rather related to cognitive competence.
Related Links	https://bmcneurosci.biomedcentral.com/counter/pdf/10.1186/1471-2202-11-113.pdf
Ending Page	10
Page Count	10
Starting Page	1
File Format	HTM / HTML
ISSN	14712202
DOI	10.1186/1471-2202-11-113
Journal	BMC Neuroscience
Issue Number	1
Volume Number	11
Language	English
Publisher	BioMed Central
Publisher Date	2010-09-08
Access Restriction	Open
Subject Keyword	Neurosciences Neurobiology Animal Models Mild Cognitive Impairment Verbal Fluency Medial Temporal Lobe Hippocampal Activity Cognitive Competence
Content Type	Text
Resource Type	Article
Subject	Neuroscience Cellular and Molecular Neuroscience
Journal Impact Factor	2.4/2023
5-Year Journal Impact Factor	2.9/2023

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