NDLI: Transition of tumor-associated macrophages from MHC class IIhi to MHC class IIlow mediates tumor progression in mice

Content Provider	Springer Nature : BioMed Central
Author	Wang, Benfan Li, Qinyan Qin, Li Zhao, Siting Wang, Jinyan Chen, Xiaoping
Abstract	Background Tumor-associated macrophages (TAMs) are the most abundant immune cells within the tumor stroma and play a crucial role in tumor development. Although clinical investigations indicate that high levels of macrophage (MΦ) infiltration into tumors are associated with a poor prognosis, the exact role played by TAMs during tumor development remains unclear. The present study aimed to investigate dynamic changes in TAM major histocompatibility complex (MHC) class II expression levels and to assess the effects of these changes on tumor progression. Results Significant inhibition of tumor growth in the murine hepatocellular carcinoma Hepa1-6 model was closely associated with partial TAM depletion. Strikingly, two distinct TAM subsets were found to coexist within the tumor microenvironment during Hepa1-6 tumor development. An MHC class IIhi TAM population appeared during the early phase of tumor development and was associated with tumor suppression; however, an MHC class IIlow TAM population became increasingly predominant as the tumor progressed. Conclusions Tumor progression was positively correlated with increasing infiltration of the tumor tissues by MHC class IIlow TAMs. Thus, targeting the transition of MΦ may be a novel strategy for drug development and immunotherapy.
Related Links	https://bmcimmunol.biomedcentral.com/counter/pdf/10.1186/1471-2172-12-43.pdf
Ending Page	12
Page Count	12
Starting Page	1
File Format	HTM / HTML
ISSN	14712172
DOI	10.1186/1471-2172-12-43
Journal	BMC Immunology
Issue Number	1
Volume Number	12
Language	English
Publisher	BioMed Central
Publisher Date	2011-08-04
Access Restriction	Open
Subject Keyword	Immunology Allergology Vaccine Cytokines and Growth Factors Major Histocompatibility Complex Major Histocompatibility Complex Class Tumor Microenvironment Promote Tumor Growth Tumor Inoculation
Content Type	Text
Resource Type	Article
Subject	Immunology
Journal Impact Factor	2.9/2023
5-Year Journal Impact Factor	3.3/2023

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