NDLI: P1.51 Effects of Electrical Baroreceptor Stimulation on Central Arterial Hemodynamics Assessed in a Large Animal Model

Content Provider	Springer Nature : BioMed Central
Author	Segers, P. Georgakopoulos, D.
Abstract	Electrical stimulation of the carotid baroreceptor has been shown to be an effective therapy for patients with (resistant) hypertension. However, the exact mechanism leading to blood pressure reduction is not fully elucidated. We measured left ventricular pressure and volume, ascending and abdominal aortic pressure using high-fidelity transducers in 9 anaesthetized dogs (24.8 ± 2.9 kg) at baseline and during electrical stimulation of the carotid baroreceptors. Therapy significantly (all P<0.001) lowered mean (from 81.1±7.6 to 54.8±5.5 mmHg), systolic (from 95.7±7.8 to 78.6±6.0 mmHg) and diastolic (from 66.6±8.3 to 41.4±6.2 mmHg) pressures. Cardiac output remained unchanged, but stroke volume tended to increase while heart rate decreased (83.5±15.3 to67.2±19.3 beats/min, P = 0.002). Systemic vascular resistance decreased from 1.25±0.50 to 0.92±0.44 AU, P = 0.002). There was no change in central-to abdominal pulse transit time, and we could not unequivocally demonstrate a change in total arterial compliance. Therapy had a drastic effect on the morphology of the pressure waveforms and on the relationship between abdominal and central aortic pressure. Pressure was amplified at baseline but damping of the pressure pulse along the aorta was observed during stimulation, suggesting a drastic impact of therapy on pressure wave reflection. This was confirmed by a decrease in the magnitude of wave reflection (from 0.54±0.13 to 0.39±0.08, P = 0.014). We conclude that, in an acute animal model, carotid baroreceptor stimulation significantly lowers blood pressure through vasodilation, with important effects on patterns of wave reflection. Further research is mandatory in experimental (conscious) models of hypertension and in patients.
Related Links	https://arteryresearch.biomedcentral.com/counter/pdf/10.1016/j.artres.2008.08.358.pdf
Ending Page	104
Page Count	1
Starting Page	104
File Format	HTM / HTML
ISSN	18764401
DOI	10.1016/j.artres.2008.08.358
Journal	Artery Research
Issue Number	3
Volume Number	2
Language	English
Publisher	BioMed Central
Publisher Date	2008-09-15
Access Restriction	Open
Subject Keyword	Medicine Public Health Medicine/Public Health
Content Type	Text
Resource Type	Synopsis
Subject	Physiology (medical) Physiology
Journal Impact Factor	0.9/2023
5-Year Journal Impact Factor	0.7/2023

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