| Content Provider | Springer Nature : BioMed Central |
|---|---|
| Author | Casuso, Rafael Antonio Martínez-López, Emilio José Hita-Contreras, Fidel Camiletti-Moiron, Daniel Martínez-Romero, Rubén Cañuelo, Ana Martínez-Amat, Antonio |
| Abstract | The purpose of this study was to investigate whether the combination of oral quercetin (Q) supplementation and exercise prevents mitochondrial biogenesis. Four groups of Wistar rats were tested: quercetin-sedentary (Q-sedentary); quercetin-exercised (Q-exercised); no-quercetin-sedentary (NQ-sedentary); and no-quercetin-exercised (NQ-exercised). Treadmill exercise training took place 5 days a week for 6 weeks. Quercetin groups were supplemented with 25 mg/kg of quercetin throughout the experimental period. Sirtuin 1 (SIRT1), peroxisome-proliferator-activated receptor γ coactivator-1α (PGC-1α) mRNA levels and the activity of citrate synthase (CS) were measured in the brain. Redox status was also quantified by measuring the enzymatic activity of catalase (CAT) and superoxide dismutase (SOD) and protein carbonyls content (PCC). Q-Exercised (P < 0.001) and Q-sedentary (P = 0.042) groups increased PCC. In the Q-sedentary, there was an antioxidant enzymatic activity modulation for CAT (P < 0.001) and SOD (P < 0.01) but not in the Q-exercised. Q-sedentary showed a similar response to exercise in the brain by increasing CS activity in the brain (P < 0.01) and by activating the transcription of SIRT1 (P < 0.001) and PGC-1α (P = 0.03). These effects were hampered in the Q-exercised group. Quercetin is a pro-oxidant agent in the brain, but it modulates antioxidant activity in a sedentary condition. Quercetin supplementation during exercise compromises mitochondrial biogenesis induced separately by quercetin and exercise. |
| Related Links | https://genesandnutrition.biomedcentral.com/counter/pdf/10.1007/s12263-014-0420-8.pdf |
| Ending Page | 8 |
| Page Count | 8 |
| Starting Page | 1 |
| File Format | HTM / HTML |
| ISSN | 18653499 |
| DOI | 10.1007/s12263-014-0420-8 |
| Journal | Genes & Nutrition |
| Issue Number | 5 |
| Volume Number | 9 |
| Language | English |
| Publisher | BioMed Central |
| Publisher Date | 2014-08-05 |
| Access Restriction | Open |
| Subject Keyword | Human Genetics Clinical Nutrition Gene Function Biomedicine Quercetin Exercise Brain Mitochondria Redox status |
| Content Type | Text |
| Resource Type | Article |
| Subject | Endocrinology, Diabetes and Metabolism Genetics |
| Journal Impact Factor | 3.3/2023 |
| 5-Year Journal Impact Factor | 3.8/2023 |
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