NDLI: Studies on intestinal transport of ginsenoside compatibility with Veratrum nigrum via Caco-2 cell monolayer model coupled with UPLC-ESI-MS method

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Studies on intestinal transport of ginsenoside compatibility with Veratrum nigrum via Caco-2 cell monolayer model coupled with UPLC-ESI-MS method

Content Provider	Springer Nature Link
Author	Ma, Yinghui Wei, Mengying Liu, Yuanyuan Song, Fengrui Liu, Zhongying Pi, Zifeng
Copyright Year	2015
Abstract	The Caco-2 cells have been recognized as effective tools to be applied to imitating the drug absorption in human intestine for the transport of drug. Herein, Caco-2 cell monolayer model was used to study the transport of the ginsenoside compatibility with Veratrum nigrum in different proportions. A specific high performance liquid chromatography-electrospray ionization-mass spectrometry(HPLC-ESI-MS) method was developed for the semiquantitative determination of ginsenoside in intestinal transport with Dioscin as an internal standard. For the Caco-2 model constructed, two influencing factors were investigated, including time and concentration. The results suggest that the absorption of ginsenoside Re, Rg1, Rb1, Rc, Rb2 and Rd are time- and concentration-dependent and the excretions of Rb1, Rc, Rb2 and Rd have a relatronship with some transport proteins. The bioavailability of the ginsenosides has reduced compared to the single Panax ginseng extract when compatibility with a certain amount of Veratrum nigrum.
Starting Page	914
Ending Page	918
Page Count	5
File Format	PDF
ISSN	10059040
Journal	Chemical Research in Chinese Universities
Volume Number	31
Issue Number	6
e-ISSN	22103171
Language	English
Publisher	Jilin University and The Editorial Department of Chemical Research in Chinese Universities
Publisher Date	2015-12-22
Publisher Place	Changchun
Access Restriction	One Nation One Subscription (ONOS)
Subject Keyword	Chemistry/Food Science Analytical Chemistry Veratrum nigrum Physical Chemistry Caco-2 cell monolayer model High performance liquid chromatography-electrospray ionization-mass spectroscopy(HPLC-ESI-MS) Inorganic Chemistry Transport Panax ginseng Ginsenoside Organic Chemistry
Content Type	Text
Resource Type	Article
Subject	Chemistry Education

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