NDLI: Design, synthesis and pharmacological evaluation of novel 4-phenoxyquinoline derivatives as potential antitumor agents

Content Provider	Springer Nature Link
Author	Zhang, Meihui Hu, Gang Zhou, Shunguang Hu, Hao Xie, Lijun Zhang, Lixia Gong, Ping Jiang, Mingyan Zhang, Cuirong
Copyright Year	2015
Abstract	A series of novel 4-phenoxyquinoline derivatives containing 3-amino-2-cyano-acrylamide framework was designed and synthesized, and the in vitro cytotoxic activities of them against five cancer cell lines(HT-29, H460, A549, MKN-45, and U87MG) were evaluated. Most of the compounds exhibited moderate-to-significant cytotoxicity and high selectivity against one or more cell lines as compared with Foretinib. The studies of their preliminary structure-activity relationships(SARs) indicate that the compounds containing methyl groups, especially methyl groups at 4-position of the phenyl ring(moiety B) are more effective. Among them, compound 36 shows the most potent antitumor activities with IC$_{50}$ values of 0.04, 0.09, 0.67, 0.39 and 1.10 μmol/L against HT-29, H460, A549, MKN-45 and U87MG cell lines, respectively.
Starting Page	746
Ending Page	755
Page Count	10
File Format	PDF
ISSN	10059040
Journal	Chemical Research in Chinese Universities
Volume Number	31
Issue Number	5
e-ISSN	22103171
Language	English
Publisher	Jilin University and The Editorial Department of Chemical Research in Chinese Universities
Publisher Date	2015-09-15
Publisher Place	Changchun
Access Restriction	One Nation One Subscription (ONOS)
Subject Keyword	Chemistry/Food Science Analytical Chemistry Physical Chemistry Inorganic Chemistry 4-Phenoxyquinoline derivative Cytotoxic activity 3-Amino-2-cyano-acrylamide Organic Chemistry
Content Type	Text
Resource Type	Article
Subject	Chemistry Education

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