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| Content Provider | Springer Nature Link |
|---|---|
| Author | Jeong, Jae Han Lee, Kyung Min Kang, Mean Hyung Kim, Sung Rae Ahn, Byeong Kil Choi, Young Wook Lee, Sang Gon |
| Copyright Year | 2012 |
| Abstract | Topical formulation of retinyl retinoate (RR) was developed with nanostructured lipid carriers (NLCs), composed of Compritol or Precirol as a solid lipid, canola oil as an oil, and Tween 80 as a surfactant. Hot high pressure homogenization method was efficiently employed to yield a homogenous nanodispersion in the size range of 230–300 nm with PDI values of <0.2, regardless of lipid selection. Precirol-based NLC (P-NLC) showed higher drug entrapment than that of Compritol-based NLC (C-NLC): RR encapsulation efficiency (%) of P- and C-NLC was 97.8 and 93.8 in average, respectively; drug loading (mg RR/g lipid) was 89.6 and 83.3 in average, respectively. Processing condition at relatively low temperature of 60 °C was a key factor for maintaining RR stability. Drug release of P-NLC was greater than that of C-NLC, even though both NLCs revealed controlled release pattern. Therefore, P-NLC system was considered as a suitable vehicle for topical drug delivery, especially for heat-labile ingredient like RR. |
| Starting Page | 243 |
| Ending Page | 250 |
| Page Count | 8 |
| File Format | |
| ISSN | 20935552 |
| Journal | Journal of Pharmaceutical Investigation |
| Volume Number | 42 |
| Issue Number | 5 |
| e-ISSN | 20936214 |
| Language | English |
| Publisher | Springer Netherlands |
| Publisher Date | 2012-09-13 |
| Publisher Place | Dordrecht |
| Access Restriction | One Nation One Subscription (ONOS) |
| Subject Keyword | Nanostructured lipid carriers High pressure homogenization Processing stability Topical delivery Retinyl retinoate Biomedicine general |
| Content Type | Text |
| Resource Type | Article |
| Subject | Pharmaceutical Science |
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