NDLI: Pharmaceutical perspectives for the delivery of TNF-α in cancer therapy

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Journal of Pharmaceutical Investigation : Volume 42, Issue 5, October 2012

Journal of Pharmaceutical Investigation : Volume 42, Issue 4, August 2012

Journal of Pharmaceutical Investigation : Volume 42, Issue 3, June 2012

Journal of Pharmaceutical Investigation : Volume 42, Issue 2, April 2012

Journal of Pharmaceutical Investigation : Volume 42, Issue 1, February 2012

Pharmaceutical perspectives for the delivery of TNF-α in cancer therapy

Content Provider	Springer Nature Link
Author	Lee, Mee Yeon Kang, Min Ju Kim, Geon Kim, Dae Duk Park, Ju Hwan
Copyright Year	2012
Abstract	TNF-α is an endogenous signaling protein which controls physiological activities and participates in immune response. It is known to interact with TNF receptors (TNFR), of which have two kinds leading to totally different effects. Binding of TNF-α to TNFR1 can induce either cell proliferation or cell death, i.e., necroptosis, depending on the kinds of protein to which it binds during the signaling cascade. On the contrary, binding of TNF-α to TNFR2 induces only cell death process. TNF-α can also cause antiviral effect by inducing interferon, and can inhibit tumor growth. Moreover, TNF-α helps action of immune cells and it leads to increasement of tumor cell lysis. TNF-α also makes tumor vessels more permeable and induces coagulation and thrombosis in the tumor vessels, which ultimately contribute to antitumor effect. However, TNF-α also has several toxic effects, which include the change in redox status of antioxidant factors, induction of excess inflammation response, and action as pro-inflammatory cytokine of itself. These toxicities need to be considered when developing TNF-α as an anticancer agent. In this review, pharmaceutical approaches to optimize and utilize its antitumor activity of TNF-α as well as to decrease its adverse effect are discussed.
Starting Page	293
Ending Page	307
Page Count	15
File Format	PDF
ISSN	20935552
Journal	Journal of Pharmaceutical Investigation
Volume Number	42
Issue Number	6
e-ISSN	20936214
Language	English
Publisher	Springer Netherlands
Publisher Date	2012-10-28
Publisher Place	Dordrecht
Access Restriction	One Nation One Subscription (ONOS)
Subject Keyword	Immunomodulating effect Tumor necrosis factor-alpha TNF-α Antitumor activity Delivery Biomedicine general
Content Type	Text
Resource Type	Article
Subject	Pharmaceutical Science

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