NDLI: Enhanced transdermal delivery and optimization of nano-liposome preparation using hydrophilic drug

Please wait, while we are loading the content...

Determination of endocrine disrupting chemicals in water samples by dispersive liquid–liquid microextraction combined with liquid chromatography–fluorescence detection

Polysaccharides-based spray-dried microspheres for maintained stability and controlled release of protein

Fabrication of levofloxacin-loaded nanofibrous scaffolds using coaxial electrospinning

Tributyrin emulsion as a potent inhibitor of serum- or heregulin-stimulated proliferation of colon cancer cells

Drug stabilization and controlled release from AB$_{3}$ type tetra block copolymer based polymersome

Journal of Pharmaceutical Investigation : Volume 42, Issue 1, February 2012

Enhanced transdermal delivery and optimization of nano-liposome preparation using hydrophilic drug

Content Provider	Springer Nature Link
Author	Park, Jun Bom Jung, Jae Hyuk Noh, Hyung gon Kang, Chin Yang Kim, Jung Mi
Copyright Year	2012
Abstract	The aim of this study is the appropriate manufacture of nano-liposome and evaluation of transdermal drug delivery after drug was loaded in liposome for topical site especially nose. To make small, stable, uniform and highly encapsulated nano-liposome, many factors including solvent, stabilizer, pH balance, homogenization speed, sonication time and filtration are critical. Especially, stearate series surfactants have positive effects on liposome size and long-term stability. In this experiment, unsaturated lecithin and Pseudoephedrine HCl (PSE) were selected for the surfactant and model drug, respectively. The unsaturated lecithin, one of the surfactants used to make the liposome, has excellent skin affinity and penetration. Tween 20 and Tween 80, support emulsifying agents, propylene glycol, a lecithin solvent and triethanolamine as stabilizer were also used as materials for liposome. Nano-liposome was made with a high shear homogenizer and pulverized by ultrasonicator to reduce the size and increase uniformity. After that, a transdermal experiment was conducted with Franz-cells on hairless mouse skin and PSE was determined by HPLC. Based on the results of the experiments, when the appropriate concentrations of support emulsifying agent and stabilizer were added, the average size of the liposome was about 300 nm and the encapsulation rate was close up to 40%. Moreover, with faster mixing speed and longer sonication time, more uniform and smaller particles tended to be manufactured. In the skin permeation test, PSE entrapped in liposome had 20 times higher permeability than PSE raw material.
Starting Page	57
Ending Page	63
Page Count	7
File Format	PDF
ISSN	20935552
Journal	Journal of Pharmaceutical Investigation
Volume Number	42
Issue Number	2
e-ISSN	20936214
Language	English
Publisher	Springer Netherlands
Publisher Date	2012-04-03
Publisher Place	Dordrecht
Access Restriction	One Nation One Subscription (ONOS)
Subject Keyword	Encapsulation rate PSE HCl Lecithin Nano-liposome Transdermal test Biomedicine general
Content Type	Text
Resource Type	Article
Subject	Pharmaceutical Science

Sl.	Authority	Responsibilities	Communication Details
1	Ministry of Education (GoI), Department of Higher Education	Sanctioning Authority	https://www.education.gov.in/ict-initiatives
2	Indian Institute of Technology Kharagpur	Host Institute of the Project: The host institute of the project is responsible for providing infrastructure support and hosting the project	https://www.iitkgp.ac.in
3	National Digital Library of India Office, Indian Institute of Technology Kharagpur	The administrative and infrastructural headquarters of the project	Dr. B. Sutradhar bsutra@ndl.gov.in
4	Project PI / Joint PI	Principal Investigator and Joint Principal Investigators of the project	Dr. B. Sutradhar bsutra@ndl.gov.in Prof. Saswat Chakrabarti will be added soon
5	Website/Portal (Helpdesk)	Queries regarding NDLI and its services	support@ndl.gov.in
6	Contents and Copyright Issues	Queries related to content curation and copyright issues	content@ndl.gov.in
7	National Digital Library of India Club (NDLI Club)	Queries related to NDLI Club formation, support, user awareness program, seminar/symposium, collaboration, social media, promotion, and outreach	clubsupport@ndl.gov.in
8	Digital Preservation Centre (DPC)	Assistance with digitizing and archiving copyright-free printed books	dpc@ndl.gov.in
9	IDR Setup or Support	Queries related to establishment and support of Institutional Digital Repository (IDR) and IDR workshops	idr@ndl.gov.in

Preparation and characterization of metoprolol tartrate containing matrix type transdermal drug delivery system

Development of transdermal drug delivery system of selegiline

Development of matrix based transdermal delivery system for ketotifen

The feasibility study of transdermal drug delivery systems for antidepressants possessing hydrophilicity or hydrophobicity

Formulation and in vitro evaluation of transdermal drug delivery system for donepezil

Development of cataplasmic transdermal drug delivery system containing eutectic mixture of lidocaine and prilocaine

Optimization and evaluation of pluronic lecithin organogels as a transdermal delivery vehicle for sinomenine.

Enhanced skin delivery of vismodegib by microneedle treatment

Preparation and optimization of tablets containing a self-nano-emulsifying drug delivery system loaded with rosuvastatin.

Enhanced transdermal delivery and optimization of nano-liposome preparation using hydrophilic drug

Similar Documents

Preparation and characterization of metoprolol tartrate containing matrix type transdermal drug delivery system

Development of transdermal drug delivery system of selegiline

Development of matrix based transdermal delivery system for ketotifen

The feasibility study of transdermal drug delivery systems for antidepressants possessing hydrophilicity or hydrophobicity

Formulation and in vitro evaluation of transdermal drug delivery system for donepezil

Development of cataplasmic transdermal drug delivery system containing eutectic mixture of lidocaine and prilocaine

Optimization and evaluation of pluronic lecithin organogels as a transdermal delivery vehicle for sinomenine.

Enhanced skin delivery of vismodegib by microneedle treatment

Preparation and optimization of tablets containing a self-nano-emulsifying drug delivery system loaded with rosuvastatin.

Enhanced transdermal delivery and optimization of nano-liposome preparation using hydrophilic drug