NDLI: Calcium Microcrystal Formation in Recurrent Herniation Patients After Autologous Disc Cell Transplantation

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Calcium Microcrystal Formation in Recurrent Herniation Patients After Autologous Disc Cell Transplantation

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Calcium Microcrystal Formation in Recurrent Herniation Patients After Autologous Disc Cell Transplantation

Content Provider	Springer Nature Link
Author	Ludtka, C. Meisel, H. J. Schwan, S. Friedmann, A. Mendel, T. Heilmann, A. Kaden, I. Goehre, F.
Copyright Year	2017
Abstract	Autologous disc cell transplantation (ADCT) is a cell-based therapy aiming to initiate regeneration of intervertebral disc (IVD) tissue, but little is known about potential risks. This study aims to investigate the presence of structural phenomena accompanying the transformation process after ADCT treatment in IVD disease. Structural phenomena of ADCT-treated patients (Group 1, n = 10) with recurrent disc herniation were compared to conventionally-treated patients with recurrent herniation (Group 2, n = 10) and patients with a first-time herniation (Group 3, n = 10). For ethical reasons, a control group of ADCT patients who did not have a recurrent disc herniation was not possible. Tissue samples were obtained via micro-sequestrectomy after disc herniation and analyzed by micro-computed tomography, scanning electron microscopy, energy dispersive spectroscopy, and histology in terms of calcification zones, tissue structure, cell density, cell morphology, and elemental composition. The major differentiator between sample groups was calcium microcrystal formation in all ADCT samples, not found in any of the control group samples, which may indicate disc degradation. The incorporation of mineral particles provided clear contrast between the different materials and chemical analysis of a single particle indicated the presence of magnesium-containing calcium phosphate. As IVD calcification is a primary indicator of disc degeneration, further investigation of ADCT and detailed investigations assessing each patient’s Pfirrmann degeneration grade following herniation is warranted. Structural phenomena unique to ADCT herniation prompt further investigation of the therapy’s mechanisms and its effect on IVD tissue. However, the impossibility of a perfect control group limits the generalizable interpretation of the results.
Starting Page	803
Ending Page	814
Page Count	12
File Format	PDF
ISSN	17382696
Journal	Tissue Engineering and Regenerative Medicine
Volume Number	14
Issue Number	6
e-ISSN	22125469
Language	English
Publisher	Korean Tissue Engineering and Regenerative Medicine Society
Publisher Date	2017-09-22
Publisher Place	Seoul
Access Restriction	One Nation One Subscription (ONOS)
Subject Keyword	Biomedical Engineering Stem Cells Recurrent disc herniation Regenerative Medicine/Tissue Engineering Disc calcification Intervertebral disc Regenerative therapy Cell Biology
Content Type	Text
Resource Type	Article
Subject	Medicine Biomedical Engineering

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Calcium Microcrystal Formation in Recurrent Herniation Patients After Autologous Disc Cell Transplantation