NDLI: Autologous bone-marrow mesenchymal cell induced chondrogenesis: Single-stage arthroscopic cartilage repair

Please wait, while we are loading the content...

Implantation of adipose tissue-derived mesenchymal stem cells in degenerative intervertebral disc of rat: When is the most effective time during the degeneration period

Silk fibroin based hydrogel for regeneration of burn induced wounds

Preparation of erythromycin-loaded poly(vinylalcohol) film and investigation of its feasibility as a transdermal delivery carrier

Substance P modulates properties of bone marrow-derived mesenchymal stem cells

CD45+/CD11b+ monocytes are required for mesenchymal stem cell proliferation In Vitro

Effect of millimeter wave for differentiation of bone marrow stromal cells to osteoblasts-like cell

The responses of human adipose-derived mesenchymal stem cells on polycaprolactone-based scaffolds: an in vitro study

Autologous bone-marrow mesenchymal cell induced chondrogenesis: Single-stage arthroscopic cartilage repair

Tissue Engineering and Regenerative Medicine : Volume 11, Issue 2, April 2014

Tissue Engineering and Regenerative Medicine : Volume 11, Issue 1, Supplement,February 2014

Tissue Engineering and Regenerative Medicine : Volume 11, Issue 1, February 2014

Tissue Engineering and Regenerative Medicine : Volume 10

Tissue Engineering and Regenerative Medicine : Volume 9

Autologous bone-marrow mesenchymal cell induced chondrogenesis: Single-stage arthroscopic cartilage repair

Content Provider	Springer Nature Link
Author	Bilagi, Praveen Shetty, Asode Ananthram Lee, Hyun Jin Shetty, Neha Shetty, Vishvas Kim, Seok Jung Stelzeneder, David
Copyright Year	2014
Abstract	We describe a single stage arthroscopic procedure for the treatment of articular cartilage defects in the knee. The novel procedure involves microfracture and application of bone marrow aspirate concentrate cells (BMAC) with hyaluronic acid and fibrin gel. The aim of the study was to evaluate the clinical and radiological outcomes at 2 years. A prospective study of 30 patients with symptomatic ICRS grade III/IV chondral defects, ranging from 2–9 cm$^{2}$, who were assessed clinically and radiologically. The surgical procedure involved debridement of the lesion, microfracture and application of concentrated BMAC with HA and fibrin gel under CO$_{2}$ insufflation. Patients underwent morphological MRI, quantitative T2-mapping and d-GEMRIC scan. Clinical assessment used the Lysholm, IKDC and KOOS scores. Radiological assessment used the MOCART score. At 2 year follow-up, Lysholm score was 80.1, as compared to 50.8 pre-operatively (p < 0.05). KOOS (symptomatic) was 92.1, as compared to 65.7 pre-operatively. IKDC (subjective) was 83, up from 39 preoperatively. The mean T2 relaxation-times for the repair tissue and native cartilage were 29.1 and 29.9 respectively. Average MOCART score for all lesions was 72. Our technique shows encouraging clinical results at 2 year follow-up. Clinical outcome scores show significant benefit. The morphological MRI shows good cartilage defect filling and the biochemical MRI (T2*-mapping) suggests hyaline like repair tissue.
Starting Page	247
Ending Page	253
Page Count	7
File Format	PDF
ISSN	17382696
Journal	Tissue Engineering and Regenerative Medicine
Volume Number	11
Issue Number	3
e-ISSN	22125469
Language	English
Publisher	Korean Tissue Engineering and Regenerative Medicine Society
Publisher Date	2014-05-14
Publisher Place	Seoul
Access Restriction	One Nation One Subscription (ONOS)
Subject Keyword	Biomedical Engineering Stem Cells Regenerative Medicine/Tissue Engineering knee arthroscopy cartilage repair fibrin bone marrow aspirate concentrate cells (BMAC) hyaluronic acid Cell Biology
Content Type	Text
Resource Type	Article
Subject	Medicine Biomedical Engineering

Sl.	Authority	Responsibilities	Communication Details
1	Ministry of Education (GoI), Department of Higher Education	Sanctioning Authority	https://www.education.gov.in/ict-initiatives
2	Indian Institute of Technology Kharagpur	Host Institute of the Project: The host institute of the project is responsible for providing infrastructure support and hosting the project	https://www.iitkgp.ac.in
3	National Digital Library of India Office, Indian Institute of Technology Kharagpur	The administrative and infrastructural headquarters of the project	Dr. B. Sutradhar bsutra@ndl.gov.in
4	Project PI / Joint PI	Principal Investigator and Joint Principal Investigators of the project	Dr. B. Sutradhar bsutra@ndl.gov.in Prof. Saswat Chakrabarti will be added soon
5	Website/Portal (Helpdesk)	Queries regarding NDLI and its services	support@ndl.gov.in
6	Contents and Copyright Issues	Queries related to content curation and copyright issues	content@ndl.gov.in
7	National Digital Library of India Club (NDLI Club)	Queries related to NDLI Club formation, support, user awareness program, seminar/symposium, collaboration, social media, promotion, and outreach	clubsupport@ndl.gov.in
8	Digital Preservation Centre (DPC)	Assistance with digitizing and archiving copyright-free printed books	dpc@ndl.gov.in
9	IDR Setup or Support	Queries related to establishment and support of Institutional Digital Repository (IDR) and IDR workshops	idr@ndl.gov.in

Erratum to: Autologous Bone-marrow Mesenchymal Cell induced Chondrogenesis: Single-stage Arthroscopic Cartilage Repair

Erratum to: Autologous Bone-marrow Mesenchymal Cell induced Chondrogenesis: Single-stage Arthroscopic Cartilage Repair

Autologous bone marrow mesenchymal cell induced chondrogenesis for the treatment of osteoarthritis of knee

A systematic review of the concept and clinical applications of Bone Marrow Aspirate Concentrate in Orthopaedics

Novel repair technique for articular cartilage defect using a fibrin and hyaluronic acid mixture

Bone Marrow Aspirate Concentrate: Its Uses in Osteoarthritis

Bone Marrow Aspirate Concentrate versus Platelet Rich Plasma or Hyaluronic Acid for the Treatment of Knee Osteoarthritis

Bone Marrow Aspirate Concentrate for Cartilage Defects of the Knee: From Bench to Bedside Evidence

Comparison of chondrogenesis-related biological behaviors between human urine-derived stem cells and human bone marrow mesenchymal stem cells from the same individual

Autologous bone-marrow mesenchymal cell induced chondrogenesis: Single-stage arthroscopic cartilage repair

Similar Documents

Erratum to: Autologous Bone-marrow Mesenchymal Cell induced Chondrogenesis: Single-stage Arthroscopic Cartilage Repair

Erratum to: Autologous Bone-marrow Mesenchymal Cell induced Chondrogenesis: Single-stage Arthroscopic Cartilage Repair

Autologous bone marrow mesenchymal cell induced chondrogenesis for the treatment of osteoarthritis of knee

A systematic review of the concept and clinical applications of Bone Marrow Aspirate Concentrate in Orthopaedics

Novel repair technique for articular cartilage defect using a fibrin and hyaluronic acid mixture

Bone Marrow Aspirate Concentrate: Its Uses in Osteoarthritis

Bone Marrow Aspirate Concentrate versus Platelet Rich Plasma or Hyaluronic Acid for the Treatment of Knee Osteoarthritis

Bone Marrow Aspirate Concentrate for Cartilage Defects of the Knee: From Bench to Bedside Evidence

Comparison of chondrogenesis-related biological behaviors between human urine-derived stem cells and human bone marrow mesenchymal stem cells from the same individual

Autologous bone-marrow mesenchymal cell induced chondrogenesis: Single-stage arthroscopic cartilage repair