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| Content Provider | Springer Nature Link |
|---|---|
| Author | Song, Dae Geun Um, Byung Hun Lee, Joo Young Son, Jin Ki Jung, Woo Suk Kim, Sang Min Pan, Cheol Ho |
| Copyright Year | 2012 |
| Abstract | Aldo-keto reductase family 1 member B10 (AKR1B10) belongs to a superfamily of NADPH-dependent aldo-keto reductases and is considered a biomarker of several cancers. Inhibition of recombinant human AKR1B10 (rhAKR1B10) was assayed using 31 seaweed extracts, among which, an Eisenia bicyclis extract was selected for further study. To identify the compounds in E. bicyclis responsible for inhibitory effects on rhAKR1B10, five compounds were isolated by bioactivity-guided fractionation and isolation. Among them, phlorofucofuroeckol-A (PFF-A), isolated from an ethyl acetate fraction, exhibited the greatest inhibition of rhAKR1B10. The inhibitory rate of PFF-A against rhAKR1B10 was 61.41% at 10 μM, with an IC$_{50}$ of 6.22 μM. Enzyme kinetic analyses revealed non-competitive inhibition with a K $_{D}$ of 2.76 μM. These results indicate that PFF-A from E. bicyclis may be a promising anticancer agent. |
| Starting Page | 721 |
| Ending Page | 727 |
| Page Count | 7 |
| File Format | |
| ISSN | 17382203 |
| Journal | Journal of the Korean Society for Applied Biological Chemistry |
| Volume Number | 55 |
| Issue Number | 6 |
| e-ISSN | 2234344X |
| Language | English |
| Publisher | The Korean Society for Applied Biological Chemistry |
| Publisher Date | 2012-12-13 |
| Publisher Place | Seoul |
| Access Restriction | Subscribed |
| Subject Keyword | aldo-keto reductase family 1 member B10 Applied Microbiology Biological Techniques phlorofucofuroeckol-A aldo-keto reductase phlorotannins Bioorganic Chemistry Eisenia bicyclis |
| Content Type | Text |
| Resource Type | Article |
| Subject | Organic Chemistry Biochemistry, Genetics and Molecular Biology |
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